New approach to traumatic brain injuries

first_imgBioengineers at Harvard have, for the first time, explained how the blast of an exploding bomb can translate into subtly disastrous injuries in the nerve cells and blood vessels of the brain.The research addresses two major aspects of traumatic brain injury (TBI), with significant implications for the medical treatment of soldiers wounded by explosions.Papers published in the journals Proceedings of the National Academy of Sciences (PNAS) and the Public Library of Science’s PLoS One provide the most comprehensive explanation to date of how abrupt mechanical forces cause catastrophic physiological changes within the brain’s neurons and vasculature.“These results have been a long time coming,” says principal investigator Kevin Kit Parker, a professor of bioengineering at Harvard’s School of Engineering and Applied Sciences (SEAS) and a major in the U.S. Army. “So many young men and women are returning from military service with brain injuries, and we just don’t know how to help them.”When the brain encounters a jarring force, such as an exploding roadside bomb, its delicate tissue slams against the skull. The result, if the patient survives, can be a temporary concussion, a more dangerous hemorrhage, or long-term TBI, which can lead to the early onset of Parkinson’s or Alzheimer’s diseases.Inspired by Parker’s own military experience, the Disease Biophysics Group (based at SEAS and at the Wyss Institute for Biologically Inspired Engineering at Harvard) has taken up the cause. Using cutting-edge tissue engineering techniques — essentially creating a living brain on a chip — biologists, physicists, engineers, and materials scientists have been collaborating on the study of brain injury and potential targets for treatment.A healthy neuron (left), with its dendrites and axon intact. The damaged neuron (right) has retracted its arms, breaking essential connections with its neighbors. Photo courtesy of Matthew Hemphill, Borna Dabiri, and Sylvain GabrieleNow, researchers in the group have identified the cellular mechanism that initiates diffuse axonal injury, offering urgently needed direction for research in therapeutic treatments.Their studies show that integrins, receptor proteins embedded in the cell membrane, provide the crucial link between external forces and internal physiological changes.Integrins connect the structural components within the cell (such as actin and other cytoskeletal proteins) with the extracellular matrix that binds cells together into tissue. Collectively, this network of structural and signaling components is referred to as the focal adhesion complex.Parker’s research has demonstrated that the forces unleashed by an explosion physically disrupt the structure of the focal adhesion complex, setting off a chain reaction of destructive molecular signals within the nerve cells of the brain.Inside the neuron, integrins normally mediate the activation of the proteins RhoA and Rho kinase (ROCK). When the focal adhesion complex is disturbed, the Rho-ROCK signaling pathway goes haywire: it directs the motor protein actin to retract the cell’s armlike axons, disconnecting the neurons from each other and collapsing the cellular networks that constitute the brain“Our research has shown that abrupt mechanical forces, such as those from a blast wave and transduced by integrins, can result in neural injury,” says Matthew A. Hemphill, who with Borna Dabiri and Sylvain Gabriele, is a lead author of the paper in PLoS One. Dabiri and Hemphill are currently graduate students at SEAS, and Gabriele is a former postdoctoral fellow in Parker’s lab.“Encouragingly, we also found that treating the neural tissue with HA-1077, which is a ROCK inhibitor, within the first 10 minutes of injury, reduced the number of focal swellings,” explained Dabiri. “We think that further study of ROCK inhibition could lead to viable treatments within the near future.”A second direction of research in Parker’s lab has solved another mystery in TBI, explaining why cerebral vasospasm, a dangerous remodeling of the brain’s blood vessels, occurs more commonly in TBI caused by explosions than in other types of brain trauma.“Until now, other researchers looking at TBI focused on ion channels and membrane poration, and it was generally accepted that cerebral vasospasm was only caused by hemorrhaging. It turns out that it’s much more complicated than that,” says Patrick W. Alford, a former postdoctoral fellow in Parker’s lab and lead author of the paper in PNAS. “Integrins and Rho-ROCK signaling appear to be players in both diffuse axonal injury and cerebral vasospasm.”As reported in PNAS, the forces exerted on arteries are different during an explosive blast than during blunt force trauma. Subarachnoid hemorrhage, which can occur in very severe head injuries, is known to cause vasospasm, but Parker’s new research shows that the unique force of an explosion can also cause vasospasm by itself.The blast from an explosion creates a surge in blood pressure, which stretches the walls of the blood vessels in the brain. To study this, Parker’s team of bioengineers built artificial arteries, made of living vascular cells, and used a specialized machine to rapidly stretch them, simulating an explosion. While this stretching did not overtly damage the cellular structure, it did cause an immediate hypersensitivity to the protein endothelin-1.Endothelin-1 is known to stimulate vascular cells to absorb calcium ions, which affect actin — the same protein involved in the retraction of axons.In the 24 hours following the simulated blast, the vascular tissues hypercontract and undergo a complete phenotypic switch, disrupting the overall function of the tissue. Both of these behaviors are characteristic of cerebral vasospasm.Most importantly, as in the neural tissue, the Rho-ROCK signaling pathway plays an important role in the behavior of actin and the cells’ contraction. Parker’s team found that inhibition of Rho soon after the injury can mitigate the harmful effects of the blast on the brain’s vascular system.“We have established a toe-hold as we try to climb up on top of this problem,“ says Parker. “In many ways, this work is just the beginning.”Parker’s co-authors on the paper in PLoS One are Hemphill, currently at the University of Mons in Belgium; Dabiri; Gabriele, who is now at the University of Mons; Lucas Kerscher, a visiting student; Christian Franck, formerly a postdoctoral fellow at SEAS and now at Brown University; Josue A. Goss, a staff engineer at SEAS; and Alford, who is now at the University of Minnesota.Parker’s co-authors on the paper in PNAS are Alford, Dabiri, Goss, Hemphill, and Mark D. Brigham, a graduate student at SEAS.The Disease Biophysics Group received financial support from the Defense Advanced Research Projects Agency (DARPA) Preventing Violent Explosive Neurologic Trauma (PREVENT) Program, the Department of Defense, and the Harvard School of Engineering and Applied Sciences (SEAS). The researchers also gratefully acknowledge the use of facilities at the Harvard Center for Nanoscale Systems, a member of the National Nanotechnology Infrastructure Network (NNIN), which is funded by the National Science Foundation (NSF).last_img read more

A Q&A forum with the president

first_imgHarvard President Drew Faust addressed an open meeting Wednesday hosted by the Harvard Undergraduate Council (UC), saying that the twin concerns of sexual assault policies and campus inclusion “have forced us and urged us” to examine University life more closely.“We have to create a culture of belonging,” free of “micro-aggression, sexual dangers,” and other impediments to social freedom, she told the assembled students in her opening remarks, which were followed by a question-and-answer session. “One of my most deeply held aspirations as president has been to build a more diverse and a more welcoming Harvard.”Before an audience of 80 in Emerson Hall, Faust discussed everything from the sexual assault policies (now being revised to match federal Title IX rules on sexual discrimination in education); to inclusion and diversity (mainstays of a changing University, she said); to queries about University investments abroad, student organization funding, mental-health services, and even the dwindling storage space at Houses undergoing renovation.“We’re very glad that she’s here today,” said Gus A. Mayopoulos ’15 in his welcome. Mayopoulos, president of the UC, the student governing body, laid down a few rules, acknowledging inspiration from the Institute of Politics: questions must be 30 seconds or less, no speeches, and no chanting. “This is a forum,” he said, “not a protest.” The council had billed the event as a friendly “joust with Faust.” Seated next to Faust to moderate the session was UC Vice President Sietse K. Goffard ’15.Most prominently, Faust discussed updating policies on sexual assault, and questions about inclusion and diversity sparked by the “I, Too, Am Harvard” photo campaign and resultant discussions. Before the questions, Faust said she had been “very struck” by those issues, and outlined some related core beliefs and aspirations.Regarding the “I, Too, Am Harvard” campaign — with its implicit worries about inclusion from the 63 black students featured — Faust was admiring. She said it had generated discussion “here, and elsewhere, far beyond Harvard, about the extremely significant issues of inclusion and identity.”As for sexual assault and the many issues that raises, Faust called the topic a matter of “safety and dignity and respect.”  It was a reminder, she added, that, “All members of the Harvard community [should] feel fully a part of that community and fully able to participate in it.”Early this month, Faust named a task force chaired by former Provost Steven E. Hyman and charged it with improving the way the University responds to sexual assault. Hyman is the Harvard University Distinguished Service Professor of Stem Cell and Regenerative Biology and director of the Stanley Center for Psychiatric Research at the Broad Institute. In 2002, while provost, he founded Harvard’s Office of Sexual Assault Prevention & Response.Meanwhile, a freshly drafted policy that responds to new Title IX requirements has been submitted to the U.S. Department of Education for review.The big issues of sexual assault and inclusion have raised questions for the Harvard community, she said. Among them are “What is a community? What do we owe to one another in terms of safety and respect? What is our real identity? What are our values?”On Tuesday, Faust met with the creators of  “I, Too, Am Harvard,” a play of the same name by Kimiko Matsuda-Lawrence ’16 that debuted on March 7.  Faust said the title “challenges us to ask ourselves: What do we want to be? If we are all Harvard, how are we going to define this place?”Faust reiterated the University’s “fundamental commitment to diversity as an essential element of who were are,” adding, “We do it because it is right, and we also do it because it makes us a better institution.”Then there is the growing diversity of Harvard, she said, which is marked by an incoming freshman class “more diverse than any class that has been admitted to Harvard before.” That fact has real meaning, she said. “We see a very close relationship between diversity and excellence. When we reach out to the broadest pool of talent, we are more likely to get the most talented people to join our community.”Faust pointed to Harvard’s commitment to expanded access to the College, noting the 10th anniversary of a broadened financial aid program and an amicus legal brief filed by the University in the 2013 Supreme Court case Fisher v. University of Texas at Austin.As for inclusion, that has to accompany the principle of greater access, said Faust, who acknowledged hard work ahead in creating a more welcoming culture.The first questions were from student leaders. The opening inquiry, on plans for “concrete steps” regarding inclusion and diversity, came from Matsuda-Lawrence and Sarah F. Cole ’16, who represented black student groups. Faust said she awaited recommendations from a working group on the issues, headed by interim College Dean Donald H. Pfister, who was seated nearby. But Faust added that parts of the “I, Too, Am Harvard” campaign could help model an action plan.A line of questions emerged about mental health, stress, and suicide prevention. “The issue of stress repeats itself at Harvard for every generation,” said Faust. “We should all be talking about … countervailing forces,” such as counseling services and social outlets. Pfister said a conversation on such topics is underway among house masters and others.Responding to a question regarding investments in Argentina timber operations that have come under scrutiny, Faust noted that a member of the Harvard Management Company had penned an op-ed citing “misstatements” by opponents. “Any kind of debate about responsible investing,” she said, “must stick to the facts.”As for a claim that only 40 percent of student activity requests get funded, Faust deferred to Pfister. He said the issue merits a serious look and shows the need for more bureaucratic flexibility, “but we’re in a period of real budgetary constraints.”That question underlined a leitmotif threading through the session: Why do things take so long to be addressed?“One of the characteristics of the University is that we are a very deliberative institution,” said Faust, and the mark of a diverse institution is that diverse opinions have to be considered. “Part of it is that there is not someone who can just dictate things.”Motioning toward Mayopoulos, who wore his classic military-style uniform that included a short sword and epaulettes, Faust quipped that to implement a more dogmatic style of leadership, “I would need Gus’ sword.”last_img read more

Shults Auto Group Donates Hotspots To Jamestown Public School Students

first_imgShare:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window) JHS Principal Dana Williams and Matthew Kahm and Jillian Shults from Shults Auto Group. Submitted image.JAMESTOWN – It might be Christmas break for students at Jamestown Public Schools, but that isn’t stopping one of the area’s largest car dealers with helping them stay connected.Shults Auto Group recently donated 50 mobile hotspots for students in the Jamestown area.School leaders say the hot spots will help students who are studying at home as a result of the COVID-19 pandemic and may be without reliable Internet.“We are extremely grateful to Shults Auto Group for helping us to ensure that all students can stay connected to school when learning at home,” said Jessie Joy, JPS’ Chief Information Officer. “We know that changing financial circumstances may make it difficult for all families to maintain wireless Internet, which creates a digital divide for students who cannot access their lessons and assignments when learning remotely. This generous donation will help us to reach even more students who don’t currently have home Internet access.” Ms. Joy encourages families that do not currently have home Internet access to reach out directly to their child’s principal to request the loan of a wireless hotspot. Shults Auto Group leaders say they understand the stress this pandemic has caused so many in the local community, especially those who need to have reliable high-speed Internet to complete their coursework.“We’re providing these mobile hotspots to Jamestown area students in need during the Covid-19 pandemic to make distance learning more accessible,” said Tim Shults, President of Shults Auto Group. “The hotspots will come with pre-paid data that should last for six (6) months or so and will be distributed to area schools in the upcoming week. We’ve been able to work through this pandemic together, supporting each other and local businesses, this is just one way we feel we can make a difference to help ease the stress the pandemic has caused.”The Shults Auto Group is the largest auto group in the Southern tier. With over 400 employees, Shults Auto Group has 10 different dealerships carrying 15 different makes and 2 pre-owned resale centers.Shults Auto Group takes pride in being extremely involved in the communities where they are located through the Shults Heroes Initiative, for more information about becoming a Shults Heroes Partner visit shultsauto.com/become-a-shults-hero-partner.htm.last_img read more

Tix Now On Sale to Hear the Sweet Sound of Amazing Grace on Broadway

first_img View Comments Amazing Grace Related Shows Show Closed This production ended its run on Oct. 25, 2015 The song the world knows and the story it doesn’t…Tickets are now available to see Amazing Grace on Broadway. Starring Josh Young, Erin Mackey, Tony winner Chuck Cooper and more, the musical will begin performances at the Nederlander Theatre on June 25, under the direction of Gabriel Barre. Opening night is set for July 16.Featuring music and lyrics by Christopher Smith and a book by Smith and Arthur Giron, Amazing Grace is based on the true story behind the beloved song. A tale of romance, rebellion and redemption, the show follows one man whose incredible journey ignited a historic wave of change that gave birth to the abolitionist movement. John Newton (Young), a willful and musically talented young Englishman, faces a future as uncertain as the turning tide. Coming of age as Britain sits atop an international empire of slavery, he finds himself torn between following in the footsteps of his father—a slave trader—and embracing the more compassionate views of his childhood sweetheart (Mackey).The cast will also include Tom Hewitt, Chris Hoch, Harriett D. Foy, Laiona Michelle, Rachael Ferrera and Elizabeth Ward Land.Amazing Grace played a pre-Broadway engagement in Chicago in fall 2014.last_img read more

Trump’s loose talk on nuclear weapons suddenly very real

first_imgAs a candidate, Trump seemed to shy from nuclear weapons at times, saying the “biggest problem, to me, in the world, is nuclear, and proliferation.”He said using such weapons would be an “absolute last step.”He added in April that, “I will be the last to use nuclear weapons. It’s a horror to use nuclear weapons.”But around the same time, he flirted with the idea of actually allowing more countries – namely Japan – to have nuclear weapons.“Maybe it’s going to have to be time to change, because so many people, you have Pakistan has it, you have China has it,” he said. “You have so many other countries are now having it.”By August 2016, MSNBC host Joe Scarborough claimed that Trump had asked a foreign policy expert what good nuclear weapons were if they weren’t utilized.“Several months ago, a foreign policy expert on the international level went to advise Donald Trump,” said Scarborough, who was intermittently friendly and adversarial with Trump. David Petraeus recently expanded upon the downside of the madman strategy.“There may, again, be some merit into the madman theory until you get in a crisis.“But you do not want the other side thinking you are irrational in a crisis.“You do not want the other side thinking that you might be sufficiently irrational to conduct a first strike or to do something, you know, so-called ‘unthinkable.’”That seems to be what Corker is worried about, and comments like this won’t allay those fears.Aaron Blake is senior political reporter for The Fix.More from The Daily Gazette:Foss: Should main downtown branch of the Schenectady County Public Library reopen?EDITORIAL: Urgent: Today is the last day to complete the censusEDITORIAL: Beware of voter intimidationEDITORIAL: Find a way to get family members into nursing homesEDITORIAL: Thruway tax unfair to working motorists Categories: Editorial, OpinionWe now have an idea what prompted Secretary of State Rex Tillerson to call President Donald Trump a “moron.”NBC News is reporting that Trump had spoken openly in the preceding meeting with national security leaders about a return to a Cold War footing with nuclear weapons — what would amount to about a tenfold increase:“Trump’s comments, the officials said, came in response to a briefing slide he was shown that charted the steady reduction of U.S. nuclear weapons since the late 1960s.Trump indicated he wanted a bigger stockpile, not the bottom position on that downward-sloping curve.“According to the officials present, Trump’s advisers, among them the Joint Chiefs of Staff and Secretary of State Rex Tillerson, were surprised. “And three times, [Trump] asked about the use of nuclear weapons. Three times. He asked at one point, if we had them, why can’t we use them?”The Trump campaign denied this.As president, Trump’s comments about nukes have also resulted in some head-scratching.Back in August, Trump falsely claimed that the arsenal was “far stronger and more powerful than ever before” thanks to upgrades made on his watch.That came despite those upgrades having been virtually impossible in his short time in office and the fact that the U.S. has a fraction of the weapons it once did.Nuclear weapons also seemed to seep into Trump’s repeated threats to attack North Korea if necessary.At one point he said he would “totally destroy” North Korea if Kim Jong Un forced him to defend the U.S. or its allies.center_img This is a threat that logically one could assume would suggest the use of nuclear weaponry.On some level, this completely plays into Trump’s foreign policy strategy. I’ve written before about how Trump is fond of the “madman strategy” in which you make your foes believe you are capable of pretty much anything.The White House even seemed to agree with that characterization on Friday:“He certainly doesn’t want to lay out his game plan for our enemies,” said his spokeswoman, Sarah Huckabee Sanders. “So if you’re asking, is the president trying to, you know, do that, absolutely.”Judging by how Tillerson responded to it — and by how Senate Foreign Relations Committee Chairman Bob Corker, R-Tenn., recently suggested Trump could lead us into World War III —  it’s clear that it’s giving those intimately involved in Trump’s foreign policy plenty of heartburn.That’s partially because they know how unrealistic it is, but it’s also partially because they worry about the eventual result. Officials briefly explained the legal and practical impediments to a nuclear buildup and how the current military posture is stronger than it was at the height of the build-up.In interviews, they told NBC News that no such expansion is planned.”It was after this July 20 meeting that Tillerson reportedly offered his “moron” comment — something the State Department has pretty directly denied, even as Tillerson declined to do so personally.This is hardly the first time Trump has talked flippantly and/or unrealistically about nuclear weapons.But it does reinforce that his attitude toward them, which leaders clearly regard as amateurish and foolhardy, is seeping into official White House business.While Trump’s loose chatter about nukes might have been dismissed as campaign bluster and posturing before, it seems much more real now.Trump is disputing NBC’s story.last_img read more

IPE Conference: Lower capital requirements for green investments are ‘dangerous’, says Rohde

first_imgLast week, one of the European Commission’s vice presidents Valdis Dombrovskis, was quoted in the Financial Times (FT) as saying a “green supporting factor” for bank lending was “something we need to explore”.In its action plan set out in March 2018, the Commission’s high-level expert group on sustainable finance included the introduction of a green supporting factor in the EU prudential rules for banks and insurance companies.Officials at the European Central Bank, according to the FT, have since warned against tampering with rules designed to make bank lending less risky.Rohde appeared to back the idea of altering capital requirements on other assets linked to the climate problem, however.“Maybe we should consider that some of the so-called black or stranded assets should have much higher risk weights than today because their value in the future is put into question,” he said, adding that this was what he thought regulators should concentrate on.“But to be very supportive about green investments I think is a little bit dangerous.“I think it’s a third best – or fourth best – solution, and I would prefer much more plain instruments like carbon taxes or pure public sector regulation,” Rohde said. The European Union plan to cut banks’ capital charges for climate-friendly lending was dealt a blow from one of the bloc’s central banks yesterday, when its governor branded the idea “dangerous”.Lars Rohde, governor of the Danmarks Nationalbank told the IPE Conference in Copenhagen his bank’s message was that central banks should stress all the possibilities but also the challenges society was confronted with in the transition to a green economy.“But what is it to support this?” he asked, responding to an audience question on whether central banks could or should support green growth.“If support means that you should for example have lower risk weights for green investments I think that is quite a dangerous route to follow because risks are risks basically,” Rohde said.last_img read more

Ighalo becoming a cult hero at Man Utd despite meant to be a temporary fix

first_img Loading… Nigeria’s Odion Ighalo is quickly becoming an unlikely hero at Manchester United. The deadline day signing has already scored three goals in two starts and is making a mockery of those who doubted him. Promoted ContentYou’ve Only Seen Such Colorful Hairdos In A Handful Of Anime20 “The Big Bang Theory” Moments Only A Few Fans Knew About8 Best Movies On Amazon Prime Video To Stream Right NowFantastic-Looking (and Probably Delicious) Bread Art5 Of The World’s Most Unique Theme Parks10 Of The Dirtiest Seas In The WorldCouples Who Celebrated Their Union In A Unique, Unforgettable WayWho Is The Most Powerful Woman On Earth?Playing Games For Hours Can Do This To Your BodyA Guy Turns Gray Walls And Simple Bricks Into Works Of ArtWhy Go Veg? 7 Reasons To Do ThisThe Models Of Paintings Whom The Artists Were Madly In Love With The Nigerian is grasping his dream with both hands and giving United a decision to make as to whether they give their boyhood fan an extended stay at Old Trafford.The 30-year-old joined in January on a loan deal until the end of the season after the club failed to land Josh King from Bournemouth. Ighalo was seen a rushed, panic signing as Ole Gunnar Solskjaer desperately looked to add another attacking option to his squad. The former Watford man was hardly on the radar of other Premier League clubs, plying his trade for Shanghai Shenhua in China, and few expected he would be the answer to United’s problems. Ole Gunnar Solskjaer has been impressed with the 30-year-old and highlighted his impact Speaking to The Guardian at the start of February, Rio Ferdinand questioned whether the forward could live up to Old Trafford expectations. ‘Ighalo has played in the English Premier League before, but one thing I am concerned about is that he is coming from China… they are trying to build a league there, but the standard is not up to the Premier League.’ Paul Scholes was another former United player to suggest Ighalo would struggle to meet the level expected of him. ‘I don’t think he’s a signing for the long term,’ he told Robbie Savage’s Premier League Breakfast on BBC Radio 5 Live. ‘I think his scoring record in China is very good but is it that credible? I don’t know.’ But a goal in his first start in the Europa League against Club Brugge and two more in the FA Cup against Derby has forced both to make a u-turn. Scholes admitted the striker looked sharp against the Belgian side and predicted him to get more chances while Ferdinand said the forward offers the team a reference point and gives other players opportunities to run off him with his hold-up play. What United have been lacking this season is a box striker, someone who can play with his back to goal but also get himself in the right position to finish off chances. All three of the striker’s goals have been scored inside the penalty area with two being one-touch finishes. As well as his two starts in cup matches he has also had three brief cameo appearances off the bench in the Premier League and his manager praised his shooting accuracy. ‘He had chances against Watford, he had a very good save against Everton – there have been good saves, he doesn’t miss the target very often.’ Odion Ighalo scored two goals against Derby in only his second start for Manchester United Four of Ighalo’s five shots against Derby hit the target and his record in China was also good with a shooting accuracy of 57.3 per cent in 2018. In comparison, Marcus Rashford’s was 48.2 and 31.7 in previous campaigns. But it’s not just what he brings to the team on the pitch that United fans appreciate. The forward’s love for the club and willingness to give everything is something that has been lacking in recent squads. His signing even sparked street parties in his homeland as he became the first Nigerian to pull on the famous shirt. The unlikely January deadline day signing is grasping his dream opportunity with both hands After scoring his first United goal Ighalo told the club’s website he would ‘give his blood’ to get more opportunities. ‘This is what I dream of and what I dreamt of when I was a kid. Now it is in my hands so I have to fight for it. I will give my blood to get it. The striker is also not afraid of wearing his heart on his sleeve and has promised to dedicate every goal he scores to his late sister who was also a United fan. There are still question marks over whether Rashord and Anthony Martial are strikers or wingers but there’s no uncertainty with Ighalo. There could be more street parties in his homeland if his stay is extended beyond the summer Read Also: Ighalo sends Man Utd fans message ahead of Man City cracker The loan deal for the striker does not include an option to buy but Solskjaer has already admitted he could extend his stay beyond the summer. And with all domestic fixtures in China currently postponed due to the coronavirus outbreak, a permanent move away from the Super League could suit Ighalo. The Nigerian was meant to be a temporary fix but it looks like he could have a big role to play for the remainder of this season and beyond. FacebookTwitterWhatsAppEmail分享 last_img read more

Pearl Marie Laschober, 94

first_imgPearl Marie Laschober, 94, Greensburg, Indiana, passed away on Friday, June 3, 2016 at the Heritage House Nursing Home in Greensburg.Born October 29, 1921 in Chicago, Illinois, she was the daughter of Herman and Louise (Kammholz) Mahnke.Pearl had worked as an administrative secretary for the Elmhurst Public Schools in Elmhurst, Illinois before she moved to Greensburg.She was married to William E. Laschober on January 1, 1944 and he preceded her in death on September 26, 2003.She is survived by two daughters, Beverly (John) Karazsia, Greensburg, Janice (Robert) Capen, Cedarburg, WI; six grandchildren, John (Jennifer) Karazsia, Bradley (Heather) Karazsia, Derrick Karazsia, Laura (Brian) Haussmann, Rebecca (Hart) Moss, Emily (Joseph) Leinss; nine great grandchildren.She was preceded in death by her parents, husband; one sister, Eleanore Blevens.Visitation will be held on Tuesday from 10 a.m. to 12:00 noon at the Chapel Hill Gardens South Funeral Home in Oak Lawn, Illinois.Funeral Services will be held at 12:00 noon on Tuesday, June 7, 2016 at the funeral home.Interment will be held in the Chapel Hill Gardens South Cemetery in Oak Lawn, Illinois.Local arrangements are being handled by the Porter-Oliger-Pearson Funeral Home.Memorials may be made to the Big Brothers Big Sisters of Decatur County, PO Box 301, Greensburg, IN 47240, The Holy Trinity Lutheran Church, 1219 S. Michigan, Greensburg, IN 47240, or to the Shriners Hospital for Children.Online condolences can be made to the family at www.popfuneralhome.comLEAD Technologies Inc. V1.01last_img read more

Dorothy Marie Harrison

first_imgDorothy Marie Harrison, 88, of Milan passed away Friday December 21, 2018 at her residence.  Dorothy was born Sunday October 5, 1930 in Eastbernstadt, Kentucky the daughter of John and Cora Lee (Edwards) Hundley.  She married Elmer Harrison and he preceded her in death.  Dorothy was a homemaker and a member of Hope Baptist Church.  She enjoyed reading and working in her garden.Dorothy is survived by sons Mick Ferguson of Milan and Curtis Rosen of Kentucky, daughters Darlene Stafford of Trenton, Ohio and Sheila Hudson of Cincinnati, Ohio, 8 grandchildren, 16 great grandchildren and 6 great-great grandchildren, brother Bill Hundley and sister Joyce Hernandez both of Chicago, Illinois.  She was preceded in death by her husband Elmer and parents.A service celebrating her life will be held 10 AM Saturday, December 29, 2018 at Hope Baptist Church, 15593 US 50, Dillsboro, Indiana 47018, with Pastor Tom Holt officiating.  Burial will be at Butler Memorial Cemetery in Trenton, Ohio.  Family and friends may gather to honor and remember her 9 – 10 AM Saturday, December 29, also at the church.  Memorials may be given in honor of Dorothy to Hope Baptist Church. Filter-DeVries-Moore Funeral Home of Dillsboro entrusted with arrangements, Box 146, Dillsboro, IN, 47018, (812) 432-5480.  You may go to filterdevriesmoorefuneralhome to leave an online condolence message for the family.last_img read more

Balotelli risks fans’ wrath

first_img But he soon made amends as he raced onto a clever chipped through-ball from the impressive Kelechi Iheanacho and coolly finished with a low shot. Roma replied with a long-range strike from Miralem Pjanic but Iheanacho, a highly-rated 18-year-old Nigerian, then struck himself when he pounced on a wayward Ashley Cole backpass. The Italians levelled again three minutes from time with a well-struck Adem Ljajic free-kick but City took the honours as the game went to a shootout. Aleksandar Kolarov missed for City but goalkeeper Joe Hart came to the rescue, saving from Seydou Doumbia and Seydou Keita and impressively smashing one in himself. Sterling was taken off at half-time – along with eight other City players – but manager Manuel Pellegrini was pleased with his display. The Chilean told reporters: “Well it is always important for the strikers to score. He scored very early in the game. “He just played 45 minutes. He has worked with our team for just a few days so I am very happy with the way he played. “He demonstrated why he is here, he demonstrated not only his value as a player. He is a very young player so I think he will improve a lot in the future, playing with Yaya (Toure), David Silva and (Sergio) Kun Aguero. “I am very happy for him and very happy for our team to have bought him.” “Well done @sterling31! Best answer. Keep it up,” the Italian wrote. Balotelli, who had a difficult first season at Liverpool, later attempted to clarify his remarks after receiving some abusive replies. He tweeted: “Liverpool fans are amazing but i [email protected] will play at his best because he deserve it. He’s a good guy young and talented….. “….support him Like you always did. He gave everything to this club and respect it so i’m sad to see this. YNWA, Liverpool is a family ALWAYS.” Sterling himself was pleased with his performance after finally generating some positive headlines with his eye-catching display at the vast Melbourne Cricket Ground. “Back doing what I love doing,” the 20-year-old tweeted, along with a picture of him celebrating his goal. Sterling struck after just two minutes and 17 seconds of a game which City eventually won 5-4 on penalties after a 2-2 draw at the end of 90 minutes. The England forward’s first touch of the game was actually inauspicious, as he fell over the ball in the first minute. Sterling, who left Anfield for City in a £49million deal last week after an acrimonious transfer saga, struck inside the first three minutes of a pre-season friendly against Roma in Australia. Liverpool supporters were angered by some of Sterling’s conduct in the months preceding the move and Balotelli, a former City player, risked inflaming tensions with a congratulatory tweet. Mario Balotelli risked the wrath of Liverpool fans by tweeting a supportive message to former team-mate Raheem Sterling after his debut goal for Manchester City. Press Associationlast_img read more