Reuse this content Twitter An error message, yesterday. Photograph: Guardian Pinterest Send your letters to firstname.lastname@example.org. And if you’ve nothing better to do you can also tweet The Fiver. Today’s winner of our prizeless letter o’the day is … Rob Moline.NEWS, BITS AND BOBSHarry Kane fancies Tottenham’s chances against Real Madrid in the Champions League next month. “Of course, we know it will be tough but it’s two good teams and an open game, probably,” he roared. “It will come down to who is more clinical in the final third – hopefully, that can be us.”Manchester City are concerned that Benjamin Mendy might have Really Very Bad Knee Knack. Mendy, though, doesn’t seem quite so worried.Napoli made a right old hash of their tribute to Arkadiusz Milik last night, handing Lorenzo Insigne the wrong shirt.West Ham and Tottenham have been charged by the FA after the handbags at the London Stadium at the weekend.Something new to haunt your nightmares: Diego Costa lingering in a tunnel.Raphaël Varane has dotted the i’s and ¨ed the e’s (or one of them at least) on a new five-year contract at Real Madrid.A Romanian fifth tier game was called off after 58 minutes yesterday as all their balls had been kicked into a nearby river.THE RECAPSign up and receive the best of Big Website’s coverage, every Friday, it says here. Seems to be a curious lack of mentions for The Fiver …STILL WANT MORE? YOU’RE MY FAVOURITE WASTE OF TIMEIt takes 96 matches to complete the group stages of Big Cup, a somewhat laborious and time-consuming process when one considers that of the 16 richest clubs in last season’s competition, only Tottenham Hotspur failed to advance to the knockout stages. So, a monumental waste of everyone’s time then, which is not to say plenty of these 96 games aren’t worth watching, whether they’re serving up perfect Harry Kane hat-tricks, sweet, sweet Gareth Bale volleys towards the top corner or the peculiar spectacle of RB Leipzig striker Timo Werner asking to be substituted after 32 minutes because the noise generated by Besiktas fans was freaking him out. Bless. Tonight, further treats lie in store, with British teams Manchester United, the Queen’s Celtic and Chelsea all slated to play group games, in Russia, Belgium and Spain respectively. United play Spartak Moscow and are expected to beat them, despite being without Michael Carrick, Antonio Valencia, Paul Pogba, Marouane Fellaini and Phil Jones. In his pre-match press conference, José Mourinho stressed the need for he and his players to stay “humble”, a demand that seemed slightly ironic, coming as it did from a man who famously announced himself in England as “a special one” and has such bottomless reserves of self-regard that he makes Donald Trump seem positively self-deprecating. “Yes, we need to go into matches thinking we can dominate but we also have to accept the reality of high-level football and be humble when the opponent is on top,” he explained, pointing out that it is only on the football field that we can expect to witness any sign of his new found humility.Having masterminded enough Big Cup capitulations at Liverpool and the Queen’s Celtic to ensure he never gets too big for his boots, Brendan Rodgers takes the Scottish champions to Anderlecht tonight, in the first of two matches between the sides to decide which of the clubs will go out of Europe before Christmas and which will go out in mid to late February. Having been battered by Paris Saint-Germain in Glasgow, Brendan has urged his players to learn from what he described as a “reality check” and warned them against complacency against a team that is currently seventh in the Belgian league and already looking for its second manager of the season. “They are no mugs,” he said. “They are a good side with a good history. They haven’t started the season as they would have wanted but [Big Cup] is a great motivating factor for them to kick on.”Meanwhile in Spain, things could get a little awkward in the bowels of Atlético Madrid’s fancy new Wanda Metropolitano stadium if the Spanish side’s new recruit, Diego Costa, happens to bump into the former boss and team-mates he treated so contemptuously while sulking his way to a return to the Spanish side. Chelsea are in town, see, although Antonio Conte has said “I have no problem with Diego Costa”, with whom he last communicated through the somewhat cowardly, but invariably effective medium of break-up text during the summer. Although Atlético’s transfer embargo precludes Costa from playing for them before Christmas, he is expected to be loitering in the tunnel area ahead of tonight’s game in order to bid a fond farewell to his former team-mates and ask if one of them wouldn’t mind posting on the white Range Rover he left behind, that’s currently gathering dust in the Chelsea youth team car park. LIVE ON BIG WEBSITEJoin Barry Glendenning from 7.45pm BST for hot MBM coverage of Atlético Madrid 2-2 Chelsea, Jacob Steinberg for CSKA Moscow 1-3 Manchester United and Paul Doyle for Anderlecht 0-0 Celtic.QUOTE OF THE DAY Timo Werner doesn’t like what he hears at Besiktas. Photograph: Stuart Franklin/Bongarts/Getty Images Facebook Pinterest Share on Facebook Share on Pinterest Football “He asked to come off so I took him off. It is impossible to prepare your team for an atmosphere like this. There was a deafening noise [and] at the start of the game we were a bit affected. For me, as coach, it is important to see who I can rely on in moments like these, who is prepared to defend himself against what is going on on the pitch. To encounter such an atmosphere was too much for some” – RB Leipzig manager Ralph Hasenhüttl explains why Timo Werner was substituted after 32 minutes against Besiktas on Tuesday night.SUPPORT THE GUARDIANProducing the Guardian’s thoughtful, in-depth journalism – the stuff not normally found in this email, obviously – is expensive, but supporting us isn’t. If you value our journalism, please support us by making a one-off or recurring contribution.FIVER LETTERS“My wife is from Chesterfield, so I have a soft spot for the brilliantly-monikered Spireites (the best nickname in the Football League), despite their recent endeavours making them difficult to love. However, if they appoint Jack Lester as manager, what are the chances he’ll replicate his playing career in Derbyshire by earning himself a three-game touchline ban during the match immediately preceding the Christmas period?” – Ed Taylor.“The link to yesterday’s Fiver in the letters is a real blast from the past. In the 1980s I had an Amiga computer, whose blue screen of death featured a Guru meditation. Very happy that the old 1980s Amigas have found a new life as webservers at Fiver Towers” – Rob Moline. Trouble in paradise? PSG have failed to defuse the fallout from the Cavani and Neymar spat, writes Ed Aarons.What are the most unlikely gigs played at football stadiums? The Knowledge has the answer.Quiz! Quiz! Quiz! Quiz! Quiz? Quiz!Oh, and if it’s your thing … you can follow Big Website on Big Social FaceSpace. And INSTACHAT, TOO!GIVE US SENSIBLE SOCCER ANYDAY The Fiver Share on Messenger Pinterest Twitter Share on Twitter features Not exactly best buddies: Edinson Cavani and Neymar. Photograph: Franck Fife/AFP/Getty Images Facebook Share via Email Share on WhatsApp Topics Share on LinkedIn Twitter Facebook
Instagram/Taylor LewanMichigan State has owned Michigan on the gridiron in recent history, winning seven of the last eight matchups between the two programs. But one prominent former Wolverine is tired of living in the past, and Wednesday he had a little fun at the expense of his new Tennessee Titans teammate – a former Spartan.Former Michigan offensive tackle Taylor Lewan, who was drafted 11th overall back in 2014, apparently wasn’t a fan of what former Michigan State offensive tackle Jack Conklin, who was drafted eighth overall this year, had hanging in his locker room. Lewan, after seeing Conklin’s Spartans jersey, playfully told him to “grow up” on Instagram. He added a “Go Blue” for fun too. Lewan and Conklin are both expected to play prominent roles for the Titans this year.
“We just got to continue to get some guys back healthy, continue to eliminate mistakes and we can be a good football team,” Whisenhunt told the Arizona Cardinals radio network after the final loss of the season.If only it was that simple, because it obviously is not.Every team has injuries and every player makes mistakes. But most teams don’t suffer the type of season-crippling losing streaks the Cardinals have. So now the Cardinals have some decisions to make, and they’re likely to be made by the time 2013 arrives. The direction the franchise chooses to go will have ramifications for many years to come.Keep Whisenhunt — on a one-year deal, no less — and risk losing defensive coordinator Ray Horton to another team. Also say goodbye to the likes of Dockett, Wells and probably Wilson. Part with the coach of the last six years, though, and take a risk that you can’t actually do better than the only man to ever lead the organization to the Super Bowl. Can the Cardinals do better than Whisenhunt? We don’t know the answer to that question.What we do know, however, is Whisenhunt has a 45-51 record in Arizona, and has compiled a mark of 18-30 in the three years since Kurt Warner retired. In that time not only have the Cardinals lost their fair share of games, but they’ve also lost considerable ground in the NFC West. The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo San Francisco? Better.Seattle? Better.St. Louis? Better. A common thread among the three teams who finished ahead of Arizona in division this season is that each hired a new coach in the time since the Cardinals last finished at the top. The Cardinals should not only take note, but also follow suit. – / 22 Top Stories Derrick Hall satisfied with D-backs’ buying and selling Former Cardinals kicker Phil Dawson retires Comments Share Ken Whisenhunt’s first game as the head coach of the Arizona Cardinals came in a loss to the 49ers in San Francisco. Did his final game with the club come with the same result against the same team in the same place?Arizona falling in its season finale by a score of 27-13 Sunday was in no way a surprise. Hell, the team finishing the season with a 5-11 mark isn’t that surprising, especially when you figure eight of 12 Arizona Sports 620 personalities pegged the Cardinals to finish with six or fewer wins this season. Six times since moving to Arizona have the Cardinals finished a season 5-11, and six more times have they finished a game or two worse than that. Yet, this 5-11 season feels worse than any of those.The 2012 Cardinals started the season with a 4-0 record. The 2012 Cardinals have a playoff-caliber defense.The 2012 Cardinals have talented players dotted all throughout the roster.None of that mattered.The 2012 Cardinals are as big of a mess as any previous iteration, with a league-worst offense and a handful of veteran leaders and key players finding their way into Whisenhunt’s doghouse.Adrian Wilson and Darnell Dockett both caught Whisenhunt’s ire this season for different reasons, as did John Skelton and Beanie Wells.Whether it was from mouthing off like Wells, ineffective play like Wilson and Skelton, or for whatever it was Dockett actually did in New York, the fact is the coach tried to send a message via his most important players.It didn’t work as the mistakes, poor play and losses continued.In fact, nothing Whisenhunt did this year worked, and it’s why the Cardinals, for the second time in three years, finished a season with just five wins, which just so happens to be, according to ESPN Stats & Info, a record in futility. Grace expects Greinke trade to have emotional impact
State Rep. Lana Theis, of Brighton, was today appointed to serve as the chair of the House Insurance Committee by Speaker Tom Leonard.“I’m humbled by the opportunity to serve the people of Michigan in this role,” said Rep. Theis. “I will work with my colleagues to create insurance reforms that reflect the needs of Michigan’s people.”The Insurance Committee deliberates on various issues related to insurance, including private health insurance, Medicare and Medicaid, and auto insurance, among other issue areas.Rep. Theis was also appointed to serve as a member of the Regulatory Reform and Law and Justice committees, and will serve as the vice chair of the Judiciary committee.House committees will have their first meetings in the coming weeks.### Categories: Theis News 26Jan Rep. Theis named chair of House Insurance Committee
Richard HaltonAll seven of YouView’s shareholders have agreed to back the UK smart TV platform for at least five more years, with the BBC, ITV, Channel 4, Channel 5, BT, TalkTalk and Arqiva remaining equal shareholders. YouView has also announced that it has passed well over one million connected UK homes in the 18 months since its marketing launch.The outfit said that over three million video-on-demand plays were being requested each week, with over half of YouView’s customers watching four half-hour VoD programmes each week.YouView did not reveal the financial commitments made by its shareholders. Reports earlier this week suggested that the broadcasters shareholders were seeking to reduce their funding of the platform by up to 85%, with BT and TalkTalk, which have arguably benefited far more from the platform, taking up the slack.“We are delighted that all seven shareholders have committed to the future of YouView with a five year term. We have achieved a significant milestone with well over 1 million homes regularly using the service and high levels of usage and satisfaction as key indicators of success for the future,” said Richard Halton, YouView’s CEO.“The next phase for YouView involves ambitious developments across a range of devices and we’re looking forward to achieving our long term target of 10 million connected UK homes.”
YouTube has launched YouTube for Artists, a service designed to help musicians connect with fans, run promotional programs and get discovered. Through the YouTube for Artists site, video service will offer tips to musicians, including lessons on engaging with fans and a guide to making money on YouTube.“You can also learn about how you can sell merch and promote your shows directly within your video through cards, and have fans directly contribute money to your channel through Fan Funding. These features give you even more ways to grow both your audience and your revenue on YouTube,” said the site in a blog post announcing the launch.YouTube said that it is also working on new ways to celebrate and promote the wide range of artists on YouTube, such as the YouTube Music Awards.
Aerial View from Wisconsin Avenue and Third StreetLast updated on May 15th, 2019 at 04:48 pmThe downtown Milwaukee Business Improvement District (Milwaukee Downtown BID #21) announced today that it will move its office to The Avenue complex.Aerial View rendering of The Avenue from Wisconsin Avenue and Third StreetThe Avenue is the new name for the former Shops of Grand Avenue. The owners of the mall are redeveloping it adding office space, apartments and a first floor food hall to be called 3rd Street Market Hall. Engineering firm GRAEF-USA announced recently that it would move its headquarters from the west side to The Avenue. GRAEF will occupy 35,000 square feet of space on the building’s third floor.The Downtown BID office will occupy 5,000 square feet in the historic Matthews Building at The Avenue, located at 301 W. Wisconsin Ave. The office will open in late summer or early fall. Milwaukee Downtown BID signed a 10-year lease for the space at The Avenue. It will move there from its current location at 600 E. Wells St., near Cathedral Square Park in downtown’s East Town neighborhood.“The roots of our organization began on West Wisconsin Avenue,” said Beth Weirick, chief executive officer of Milwaukee Downtown, BID #21. “At the time, it was an important statement and location for Milwaukee Downtown, BID #21 as we launched our clean, safe and friendly programs. The same rings true today. Given the unprecedented development along Wisconsin Avenue, we hope to add vitality to the area and enhance activation.”The Milwaukee Downtown BID space will include 2,200 square feet of street-level office space where the public will be able to access a new Downtown Visitor & Newcomer Information Center, as well as the organization’s administrative office. An additional 2,800 square feet on the lower level will serve as meeting space for the Milwaukee Downtown’s Public Service Ambassador program.“We’re thrilled to welcome Milwaukee Downtown, BID #21 to The Avenue,” said Tony Janowiec, partner of The Avenue and CEO of Interstate Development Partners. “As one of downtown’s top cheerleaders, we know the organization will bring a whole new energy that will complement our offerings to visitors, residents and businesses.” Get our email updatesBizTimes DailyManufacturing WeeklyNonprofit WeeklyReal Estate WeeklySaturday Top 10Wisconsin Morning Headlines Subscribe
Add to Queue Opinions expressed by Entrepreneur contributors are their own. Niche marketing Twin brothers in Paris left the insurance business to open a restaurant catering to nude vegans. Contributor President of The Marks Group Image credit: O’naturel | Facebook Next Article Apply Now » The only list that measures privately-held company performance across multiple dimensions—not just revenue. –shares 3 min read Gene Marks 2019 Entrepreneur 360 List November 8, 2017 The Dress Code for This New Restaurant Is Your Birthday Suit If you’ve ever had the desire to eat an entire meal in public and be completely naked at the same time well…now’s your chance. Just go to Paris and make a reservation at O’naturel.Yes, that’s the actual name and at the 40-seat O’naturel, which opened its doors last week, customers are asked to leave their clothes in the cloakroom and proceed – in all their splendidness – to dine with other clothe-less patrons. The “bistronomic” menu starts around € 39 (about $45) and features vegan dishes, whitch are popular among naturists, and of course a great wine selection. This is Paris, let’s not forget.Related: Dear Entrepreneurs: Small Is Still BeautifulDon’t worry, health officials, the staff are clothed, patrons wear slippers and the seats have disposable covers.According to two reports last week here and here in Le Parisian, would-be voyeurs on the street won’t get a peep show. The establishment sports a “neutral” front, with a heavy blackout curtain and other screens covering the main windows. The entrance is designed to prevent anyone from seeing inside, even when the doors are opened. The establishment received a hearty thumbs up from members of the Association des Naturists de Paris, who were invited to be the very first diners.Related: 9 Startups Changing the Fabric of FashionThe French, being French, aren’t ruffled. In fact, residents in the restaurant’s neighborhood are mostly indifferent to its uniqueness. “When we learned what was going to be here, obviously it made us laugh. Especially since there is a nursery next door,” one resident who lives above the restaurant said. “But it does not bother me.”Even though it’s early days, things seem to be going pretty well for Mike and Stéphane Saada, the twin-brothers who own the restaurant. The Saada twins are ex-insurance industry executives and, unsurprisingly, ardent naturists. The restaurateurs are hoping to tap into the two-million strong naturist community in France. “We have already had quite a few reservations on the Internet,” they said, adding the comments coming in on their website are “very nice.”Related: 7 Steps to Defining Your Niche MarketLots of people open up restaurants and it’s no secret that many of them fail. It’s a hard and competitive business. Which is why a potential road to success is picking a demographic — whether it’s vegans, naked people or even lovers of the Golden Girls — and (of course) serving up good food. In this highly specialized world, many smart business owners I know are zeroing in on a targeted industry and becoming excellent at a particular skill to stand out and profit. So why not excellent food that caters to the community of French naturists?Oh, and the best thing about O’naturel? Well, in my opinion, it’s that no matter how high the bill is, you’ll never feel like you’ve lost your shirt.
Guest Writer Green Entrepreneur Podcast Lawmakers loath to raise taxes but eager for new revenue are increasingly open-minded about legal marijuana. August 9, 2018 Add to Queue Marijuana Is a $794 Million Windfall for the States That Have Legalized Adult Use Image credit: Hillary Kladke | Getty Images Easy Search. Quality Finds. Your partner and digital portal for the cannabis community. Each week hear inspiring stories of business owners who have taken the cannabis challenge and are now navigating the exciting but unpredictable Green Rush. Opinions expressed by Entrepreneur contributors are their own. Next Article 3 min read There are several good reasons for state lawmakers to embrace legal adult-use marijuana — criminal justice reform, ending mass incarceration, respect for individual rights — but for many the most compelling reason is this number: $793.6 million.That is the estimated 2017 total of taxes and fees raked in by five states where adult-use marijuana is legal, according to a report from the National Cannabis Industry Association. The NCIA, founded in 2010, represents about 1,500 businesses in the marijuana industry across the United States.Much of the rhetoric advocating legal marijuana revolves around arguments such as cannabis being less dangerous than alcohol or the social justice issues surrounding the implementation of drug laws. Those are strong, valid arguments but when it comes to actually changing minds, it’s wise to remember that money really does change everything.Related: Education and Employment Is High in Cannabis-Friendly StatesA windfall where the law allows it.The cannabis economy offers ambitious entrepreneurs the chance to flourish in an already competitive environment, but it’s the money governments are bringing in that is really turning heads in many public offices around the country. The NCIA-reported revenue for just five states. The numbers (rounded) from each are:Washington — $441 millionColorado — $234 millionOregon — $68.6 millionAlaska — $6.1 millionNevada — $43.7 millionThat Nevada number is particularly eye-catching because the state only started regulated sales of marijuana in July 2017.For state governments, there is simply nothing else aside from a gargantuan tax increase that can generate that much additional money this fast. Many observers think the potential for a large and reliable new source of marijuana tax revenue will push more states to legalize, just as New Hampshire’s legalization of a state lottery in 1964 prompted most other states to eventually follow suit. There are currenly just six states — Alabama, Alaska, Hawaii, Mississippi, Nevada, and Utah — without a state lottery. Related: Jimmy Kimmel’s ‘Dr. Quinn Medicinal Marijuana Woman’ Spoof Is HilariousEstimates of potential marijuana tax revenue has energized the push for legalization in other states.This talk heated up especially in Illinois last year, with even the Chicago Tribune weighing in that legalizing marijuana could help solve the state’s intractable budget problems. Voters will get a chance to approve recreational marijuana sales in November. However, it’s just an “advisory” ballot question. State lawmakers would still need to act. But a majority “yes” vote on legal adult-use cannabis would give lawmakers on the fence the political cover they need to move forward on legalization.Late last year, the Pennsylvania auditor general also advocated legalized marijuana to solve that state’s budget crisis, conservatively estimating $200 million in new revenue.Legalizing and taxing adult-use recreational marijuana is an increasingly viable option for states. The biggest barrier, as always, is lawmakers and state executives who led these states into a budget crisis in the first place. Voters who remember the promise of those who promoted state lotteries also might be skeptical about what marijuana tax dollars can accomplish.That said, for embattled state leaders, legalizing adult-use marijuana is a path more and more are willing to take — or at least seriously consider.Follow dispensaries.com on Instagram to stay up to date on the latest cannabis news. –shares dispensaries.com Legal Marijuana Listen Now
Updated E-Commerce Automation System now Supports Newegg, Rakuten, WebShopManager, ShipHero, Informed Repricer and moreSureDone, a leading multichannel e-commerce listing and order management platform that improves the efficiency and automates the online commerce of brands, enterprises and growing e-commerce sellers, has enhanced its advanced Automation Engine to support complex connection types and integration workflows required by partner APIs. Initial implementations leveraging these powerful enhancements include integrations with Rakuten and Newegg marketplaces, ShipHero 3PL and logistics, WebShopManager storefronts and Informed repricing.“Our mission for automating commerce everywhere is one step closer by abstracting automation with virtually any type of connection and data integration with SureDone,” said Jason Nadaf, Founder and CEO of SureDone. “Our enhanced automation engine capabilities are unparalleled in the ecommerce industry and allow us to pass through the value of quick integration to marketplaces and logistics tools to our users, customers and strategic partners.”SureDone’s Automation Engine is an advanced purpose built commerce data and system connector that lets connection types and field variables be defined through configuration files. The data can be imported and exported to and from SureDone to facilitate product listing, inventory management, orders, ship tracking and other logistical requirements.Marketing Technology News: Zeno Media and ADORA Cooperate on Strategic Marketing and Mobile App Content for Diaspora ListenersTo support marketplace integrations with NewEgg and Rakuten and repricing with Informed, the new capabilities include the ability to make and process multiple sequential requests for feed and job based systems. To support leveraging the 3PL fulfillment network offered via ShipHero, upgrades were introduced to support line item shipping and enhanced JSON support.“Companies needing access to niche marketplaces that no other multichannel solution supports can now leverage SureDone’s multichannel e-commerce management software using these market leading enhancements,” said Chris Labatt-Simon, Executive Vice President at SureDone. “Imagine your efficiency when you are able to consolidate listing, inventory management, order management and logistics for all channels and systems. It’s now here with SureDone.”Marketing Technology News: Adaptive Ad Systems Completes Installation of New Ad-Insertion Equipment on National Cable TV Systems Adds 40,000 Additional SubscribersSureDone’s Automation Engine currently supports FTP, SFTP, FTPS, S3, HTTP (API, SOAP, JSON and websites) and EMail connection types, and CSV, XML, JSON, XLS, XLSX, HTML, Text, PDF and several other formats and connections, in addition to EDI over sFTP with AS2 coming soon. The SureDone advanced Automation Engine is being constantly enhanced to support new capabilities and use cases.Marketing Technology News: Haoqipei Secures US $60 Million in Series D Funding to Further Accelerate Growth of its Online B2B Auto Parts Marketplace SureDone Enhances Automation Engine to Support Marketplaces and Complex Integrations MTS Staff WriterJune 25, 2019, 8:15 pmJune 25, 2019 advanced Automation Enginee-commerce listingJason NadafMarketing Technology NewsNewsorder management platformSureDone Previous ArticleNative Mobile Apps Market Expanding Massively by 2020Next ArticleMonetate Exceeds $2 Billion in Influenced Revenue and Unveils New Brand Identity and Leadership at Cannes Lions 2019
Source:http://www.cavionpharma.com/ The TETRAS Activities of Daily Living (TETRAS-ADL) scale, a measure of tremor impact on daily activities (p=0.049) The Clinician Global Impression of Improvement (CGI-I), a measurement of physician-reported global improvement (p=0.001) The TETRAS Total Score (TETRAS ADL + TETRAS-PS rated by the study Investigators, p=0.029) The Goal Attainment Scale (GAS), a measure of progress toward patient-selected goals (such as dressing oneself, writing a sentence, or drinking out of a cup) (p=0.034) Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 7 2018Cavion, Inc., a leading clinical stage biotechnology company committed to developing novel therapeutics for people with neurological diseases, today announced promising results of the T-CALM Phase 2 clinical trial of its first-in-class T-type calcium channel modulator CX-8998 in essential tremor. The company plans to present results from this proof-of-concept study as a late-breaking poster on Monday, October 8 at the International Congress of Parkinson’s Disease and Movement Disorders® in Hong Kong.Multiple secondary and exploratory endpoints collectively showed that treatment with CX-8998 10mg twice daily resulted in statistically significant improvement versus placebo in activities of daily living and patient-reported and clinical outcome measures, despite the study’s primary endpoint being missed. In the study, CX-8998 demonstrated a favorable safety and tolerability profile, with patients in the drug treatment arm reporting higher levels of satisfaction with tremor control medication compared to patients on placebo.”After decades without new effective drug therapy options, we believe that the neurostabilizing effects of CX-8998 provide hope for essential tremor patients,” said Spyros Papapetropoulos, MD, PhD, Cavion’s Executive Vice President of Research & Development and Chief Medical Officer. “The data are particularly compelling given that about two-thirds of patients in the study were on standard of care treatment and significant improvement was achieved with CX-8998 on several measures in a study lasting just one month.””Essential tremor is a challenge to treat, and patients often do not respond favorably to the existing medications, many of which have been available for decades,” said Karl Kieburtz, MD, MPH, Professor of Neurology at the University of Rochester Medical Center. “Cavion’s CX-8998 has a novel mechanism of action that may provide substantive improvement, and it could be an important therapeutic contribution above and beyond what we currently have for essential tremor. I look forward to its clinical progress and further investigation. Better medications are needed to treat this common and disabling movement disorder.”T-CALM was a 28-day, double-blind, placebo-controlled Phase 2 proof-of-concept clinical trial in 95 patients with moderate to severe essential tremor, conducted at 25 sites across the United States. Patients were randomized to receive either placebo or CX-8998 titrated up to 10mg dosed twice daily (BID). A majority of subjects (64 percent) added study drug to their existing standard of care anti-tremor medication.The primary study endpoint using remote video rating of the Tremor Research Group Essential Tremor Rating Assessment Scale – Performance Subscale (TETRAS-PS), a measure of tremor severity, did not meet significance at Day 28 (p=0.696). In contrast, the same TETRAS-PS scale rated by the study investigators who observed the patients in person resulted in a significant improvement in tremor severity at Day 28 for the CX-8998 treated group compared to placebo (p=0.027). Independent analysis of the video rating process uncovered unexpected complications in implementation. Cavion is working closely with the scientific community to enhance central video rating for use in interventional studies.Related StoriesOxidative stress could play key role in the spreading of aberrant proteins in Parkinson’s diseaseOlympus Europe and Cytosurge join hands to accelerate drug development, single cell researchResearchers challenge conventional understanding of cause of Parkinson’sMultiple secondary and exploratory endpoints collectively showed statistical significance, with benefits after 28 days of treatment in patients receiving CX-8998 10mg twice daily (BID) compared to placebo in the following scales: In addition, the Patient Global Impression of Change (PGI-C), a measure of patient-reported improvement, trended towards significance favoring CX-8998 (p=0.089). Kinesia One, an algorithm-based digital measure developed for Parkinson’s disease, failed to detect a treatment difference in Essential Tremor patients. Additional analyses, including patient satisfaction with control by anti-tremor medication and traditional and digital spirography, support a treatment benefit with CX-8998. The drug showed a favorable safety and tolerability profile, with the majority of adverse events mild to moderate, transient and non-recurring. No major differences between CX-8998 and placebo were observed in laboratory values, vital signs or electrocardiography.In addition to the T-CALM study for essential tremor, CX-8998 is currently being studied in T-WAVE, a multi-center Phase 2 clinical trial for generalized epilepsy with absence seizures. “The body of evidence supporting our ground-breaking approach is rapidly expanding,” said Andrew Krouse, President and CEO of Cavion. “Our pipeline of T-type calcium channel therapies extends beyond tremor to other neurological diseases that share a common pathophysiology. We look forward to initiating a Phase 3 study in tremor soon.”
The deployment of the J750 has been enabled thanks to funding from three partners: the European Union, the Regional Council of Nouvelle Aquitaine and the Bordeaux University Foundation, of which the CHU is a part. Source:Stratasys Jul 15 2019Bordeaux University Hospital (CHU) in France is leading the charge to improve success rates of complex kidney tumor removal surgery, thanks to unique full-color, multi-material 3D printing technology. The CHUis currently one of the only hospitals worldwide to use a Stratasys J750– the world’s only full-color, multi-material 3D printer – for complex kidney tumor removal cases. The 3D printed models are also used to enhance the explanatory process towards patients, as well as improve surgeon training.Support from patientsRelated StoriesStratasys’ new J720 Dental 3D printer sets new standards for digital dentistryStratasys advanced FDM 3D printing helps Biodonostia to improve treatment for thoracic wall tumorsStratasys and Materialise bring 3D printed medical models to lifeOne such patient is Carole Ridel, who recently underwent surgery at the CHU. “I was shown a 3D printed model of my kidney prior to my operation and instantly felt more reassured than I had been before surgeries I had undergone in the past,” she explains. “Seeing such a realistic representation allowed me to understand the process much better than an MRI scan. I noticed that the tumors were on the external wall of the kidney, rather than inside the organ itself, so I was comforted by realizing the situation wasn’t as bad as I had imagined.”Collaborative project to improve communication with patientsUsing its J750 3D Printer, CHU also recently created a collaborative research project entitled Rein 3D Print, which aims to determine whether boosting patient understanding of their surgical procedure can improve ambulatory care (same-day surgery that doesn’t necessitate an overnight stay). According to Prof. Bernhard, 3D-printed model shave contributed to the success of this pilot protocol and have reduced patient hospitalization times during pre-surgery planning. The surgical team at the CHU’sDepartment of Urology and Kidney Transplantationis3D printing life-like transparent and color models of the patient’s anatomy to help perform precise and successful kidney-sparing surgery and improve patient outcomes.Jean-Christophe Bernhard, Urology Professor at Bordeaux University Hospital, says the clearer view offered by the 3D printed model helps identify and avoid damage to the delicate nearby arteries and vessels which, in the case of complex or high-volume tumors, can result in a patient’s kidney being completely removed.Sparing the patient’s kidney is important because it reduces the chance of subsequently suffering from chronic kidney disease. Having a 3D-printed model comprising the patient’s kidney tumor, main arteries and vessels – each in a different color – provides an accurate picture of what we will see during operations. The ability to visualize the specific location of a tumor in relation to these other elements, all in three dimensions, greatly facilitates our surgical planning and is not easily achievable from a 2D scan.”Jean-Christophe Bernhard, Urology Professor, Bordeaux University Hospital The clearer view offered by a transparent, full-color 3D printed model increases the ability to perform precise and successful kidney-sparing Describing kidney tumor removal with a 2D scan or diagram will invariably leave most patients somewhat bewildered. Presenting them with a 3D printed model that clearly shows the tumor puts them at ease and enables the patient to grasp exactly what we’re going to do. Indeed, initial research from patient questionnaires shows that having 3D printed models increases their understanding of the surgery by up to 50%, so it’s a considerable benefit in terms of overall patient care.”Prof. Jean-Christophe Bernhard
Related StoriesBiden calling ACA ‘breakthrough’ for mental health parity highlights gapsPerinatal depression screenings may overlook women having suicidal ideationOlympus Europe and Cytosurge join hands to accelerate drug development, single cell researchIn her study, young adult women between the ages of 18 and 25 were scanned in a 3D scanner used by researchers and students in MU’s Department of Textile and Apparel Management. The researchers used modeling software to convert the scans to 3D avatars. Participants then digitally “painted” body parts that they appreciated for various reasons such as their utility or role in their relationships.”In digitally painting their avatars, women could think about how, for example, their thighs help them run or how their arms can help hold others in an embrace,” Ramseyer Winter said. “It provided the participants a way to visual their bodies in a completely different way. It allowed the participants to recognize how our bodies are much more than a size or a number on a scale.”Immediately and then again three months after digitally painting their avatars, participants reported increased body appreciation over time. Moreover, participants reported lower depressive and anxiety symptoms.”While more research still needs to be done on the relationship between the 3D image intervention we used and its impact on mental health, we did see a significant effect on body appreciation,” Ramseyer Winter said. “Prior research has shown that body appreciation is related to depression and anxiety, which leads us to think that we are on the right track in creating an intervention that can improve not only body image, but mental health as well.”Future research will look at how painting the 3D avatars impacts young women with more severe depression.Antoinette Landor, co-director of the Center for Body Image Research and Policy, co-authored the study. Other MU researchers who worked on the project were Michelle Teti, Kristen Morris, Erin Schliep, Danielle Pevehouse-Pfeiffer and Emily Pekarek.The study is part of the newly created Center for Body Image Research and Policy, an interdisciplinary research center housed in the MU College of Human Environmental Sciences. The center was built around the goal to improve body image, health and wellness for individuals, families and communities. Source:University of Missouri-Columbia 3D body image scanning is a relatively new tool in social science research, and the research on using 3D tools for improving body image is scant. We wanted to see if it could provide a way to help young women shift their focus away from appearance and toward function.”Virginia Ramseyer Winter, Director of the MU Center for Body Image Research and Policy Reviewed by James Ives, M.Psych. (Editor)Jun 21 20193D technology has transformed movies and medical imaging, and now it might be able to help young women better appreciate their bodies.Virginia Ramseyer Winter, assistant professor in the School of Social Work and director of the MU Center for Body Image Research and Policy, is a nationally recognized body image expert. In a new study, she found that images from 3D scanners can be used to help young women focus on body appreciation, which might in turn improve mental health.
Citation: LA to become first in US to install subway body scanners (2018, August 14) retrieved 18 July 2019 from https://phys.org/news/2018-08-la-subway-body-scanners.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further Body scanners being piloted in Los Angeles subway system In this Tuesday, Feb. 27, 2018 file photo ThruVision suicide vest-detection technology reveals an suspicious object on a man, at left, during a Transportation Security Administration demonstration in New York’s Penn Station. Los Angeles is poised to have the first mass transit system in the U.S. with body scanners that screen passengers for weapons and explosives. Officials from the Los Angeles County Metropolitan Transportation Authority and the Transportation Security Administration have scheduled a Tuesday, Aug. 14, 2018, news conference. The TSA has been working on the experimental devices, known as standoff explosive detection units, since 2004 with transit agencies. They hadn’t been deployed permanently at any transit hub. (AP Photo/Richard Drew,File) © 2018 The Associated Press. All rights reserved. The Los Angeles County Metropolitan Transportation Authority and the Transportation Security Administration had been testing several different types of body scanners for about a year.The scanners that are being deployed are portable, and project waves to do a full-body screening of passengers walking through a station without slowing them down.The machines, which scan for metallic and non-metallic objects on a person’s body, can detect suspicious items from 30 feet (9 meters) away and have the capability of scanning more than 2,000 passengers per hour, said Brian Haas, a spokesman for the Los Angeles County Metropolitan Transportation Authority.The TSA tested body scanners in New York’s Penn Station in February and has also conducted tests at Union Station in Washington, D.C., and at a New Jersey Transit station during the 2014 Super Bowl.In December, a Bangladeshi immigrant injured himself by setting off a crude pipe bomb strapped to his chest in a subway passageway near Times Square in New York City.Metro has previously tested several different types of body scanners, including airport-style screening systems where passengers walk through a scanner. The pilot program was meant to evaluate the accuracy and capacity of the portable machines.About 150,000 passengers ride on Metro’s Red Line daily and the subway system counted more than 112 million rides last year. The Los Angeles subway system will become the first in the U.S. to install body scanners that screen passengers for weapons and explosives, officials said Tuesday.
Credit: CC0 Public Domain Provided by University College London Across the globe smartphones and mobile apps have become an integral part of everyday life, but what determines the apps you use? Socio-economic factors also play an important role when considering mobile usage. The study shows that occupation, education, and how much a person has in savings, are the next most important factors in determining what apps a person will use. Socio-economic factors are more important than age and gender.People of similar socio-economic status tend to use their smartphones in a similar way across the globe. This is particularly true for people of similar household status, living with or without children, and is also true for professionals and well-educated people.Dr. Ella Peltonen, lead author on the study and postdoctoral research fellow at the Insight Centre for Data Analytics, Ireland, said: “The results of our work show that there is a strong relationship between the type of apps people use and their geographic and socio-economic factors, suggesting that these different factors should be taken into account when studying mobile data. In addition, our results can be used to better target mobile apps in different countries, and for personalisation.”Dr. Musolesi concluded: “The findings of this research can be exploited in many contexts, not only commercial ones. We can use this information for better targeting applications for positive behaviour intervention or civic participation. One specific application domain is digital health, where understanding which applications are popular in a certain region for a specific socio-economic group is of fundamental importance for effective and systematic actions such as for disease prevention, vaccination campaigns or mental health interventions at local and national level.” This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. More information: Ella Peltonen et al. The hidden image of mobile apps, Proceedings of the 20th International Conference on Human-Computer Interaction with Mobile Devices and Services – MobileHCI ’18 (2018). DOI: 10.1145/3229434.3229474 App usage soars as smartphones take hold A new study involving UCL reveals that the country you live in rather than your demographic data is actually the biggest indicator of the types of apps you download and use. The study, conducted in collaboration with the Insight Centre for Data Analytics, Ireland, University of Helsinki, Finland, and Lancaster University, UK, will be presented at the MobileHCI 2018 conference in Barcelona, Spain, September 3-6. Researchers found that English-speaking countries, including the UK, USA, Australia, Canada and New Zealand, as well as Japan and South Korea had the highest app usage, with the lowest app usage being found in Argentina, the UAE, Saudi Arabia, Qatar, Pakistan and India.Dr. Mirco Musolesi, who leads the UCL Intelligent Social System Lab (UCL Geography), said: “Previously studies have not focused on geographic and cultural factors behind app usage, instead choosing to focus on usage patterns and behaviour.”Our research highlights that even if mobile communications and hyper-connectivity are a global phenomenon, the country we live in plays a huge part in determining our app preferences. Understanding how and when people use phones, and which apps they engage with, is important for the study of individual behaviour and society at large.”The team applied large-scale analysis of geographic, cultural, and demographic factors in mobile usage, using data from 25,323 Android users who used 54,776 mobile applications in 44 countries across Europe, Americas, Asia and Oceania.While Hofstede’s Value Survey Model was used to determine cross-cultural preferences, finding that masculine cultures, as determined by the model, with more pronounced gender roles, like Japan prefer Personalization apps that help users to more easily customise their device, while collectivist cultures and those with more fluid gender roles such as Russia seem to value Family related categories, such as Education and Parenting applications. “Individualist” cultures such as the US favoured Entertainment apps and other leisure related categories, such as Travel & Local, Sports, Health and Fitness, and Music and Audio. The most popular categories for the UK are Communication apps, Social, Travel & Local, and News & Magazines. The researchers also observed that the UK is characterised by an application usage pattern that is closer to other English-speaking countries and more distant from that observed in countries in continental Europe. Explore further Citation: Geographic location biggest indicator of mobile app preferences (2018, September 5) retrieved 17 July 2019 from https://phys.org/news/2018-09-apps.html
German software giant SAP raises dividend So-called “cum-ex” and “cum-cum” deals—complex stock transactions around the days when companies pay out dividends—have cost taxpayers as much as 55 billion euros ($63 billion) in lost revenue or outright fraud since 2001.The schemes were first uncovered in Germany in 2012.But beyond Europe’s largest economy, Thursday’s investigation found evidence of the practices in France, Spain, Italy, the Netherlands, Denmark, Belgium, Austria, Finland, Norway and Switzerland.Accounting for the bulk of the total at 46 billion euros, technically legal “cum-cum” tax avoidance exploits varying treatment of domestic and foreign shareholders.Foreign investors holding shares in a company temporarily sell the stock to a bank based in the same country as the firm ahead of the day dividend gets paid out.This allows them to escape higher taxes on the dividend charged to shareholders from abroad, before buying back their holdings quickly afterwards.Such deals deprived Germany of 24.6 billion euros in tax revenue, France 17 billion and Italy 4.5 billion, according to the investigation led by investigative journalism website Correctiv with big-name outlets like German public broadcaster ARD and French newspaper Le Monde.Criminal investigationsMeanwhile, clearly fraudulent “cum-ex” deals draw in more parties in a complex dance around the taxman.Reportedly conceived by well-known German lawyer Hanno Berger, the cum-ex method relies on several investors buying and selling shares in a company amongst themselves around the day when the firm pays out its dividend.The stock changes hands so quickly that the tax authorities are unable to identify who is the true owner.Working together, the investors can claim multiple rebates for tax paid on the dividend and share out the profits amongst themselves—with the treasury footing the bill.This practice cost Germany 7.2 billion euros, Denmark 1.7 billion and Belgium 201 million, the investigation found.Since 2012 six criminal investigations have been opened in Germany, including against tax lawyer Berger and several stock market traders.Norway’s tax authority told AFP that it had uncovered a fraud worth 580,000 crowns ($70,533 or 61,304 euros) in 2013 and blocked several later attempts after a warning from Denmark.The country has since strengthened its surveillance, it added.Meanwhile Danish prosecutors have been studying tax practices around dividends since 2015 and are examining “whether there is a basis for criminal proceedings against people or companies involved,” spokesman Simon Gosvig said.Pierre Moscovici, European Commissioner for economic and financial affairs, tweeted in response to the investigation that European tax authorities should share more information and improve transparency.”If the fraudsters’ imagination is limitless, my determination is as well!” he wrote. Two closely-related tax schemes have helped banks and investors avoid tax or even syphon cash directly out of European treasuries totalling billions more than previously thought, an investigation by 19 media revealed Thursday. So-called “cum-ex” and “cum-cum” deals were first uncovered in Germany in 2001, while a 2018 media investigation found evidence of the practices in France, Spain, Italy, the Netherlands, Denmark, Belgium, Austria, Finland, Norway and Switzerland © 2018 AFP Explore further Citation: Mass tax trickery cost Europe 55 bln euros: report (2018, October 18) retrieved 17 July 2019 from https://phys.org/news/2018-10-mass-tax-trickery-europe-bln.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.