Tag: 爱上海

Griezmann wants to decide before the World Cup

Griezmann wants to decide before the World Cup

first_imgAntoine Griezmann’s situation has been very unclear lately but the Frenchman insisted that he hasn’t held any talks with Barcelona but wants to decide before the World Cup over his future.The Atletico attacker has been heavily linked with a possible move to Barcelona but he denied that he has been holding talks with the Catalonian side – but he admitted that he may leave at the end of the season.The former Real Sociedad striker spoke about his future as he said, according to Goal:“I don’t know where you get this information, but it is false.”Fati and Suarez shine against Valencia at Camp Nou Tomás Pavel Ibarra Meda – September 15, 2019 With a mesmerizing first half from Ansu Fati and a brace from Luis Suarez in the second half, Barcelona demolished Valencia at Camp Nou.Valencia…“I want to be free and think only about the French team.”“I would like my future to be settled before the World Cup, otherwise, afterwards, we will have questions to the right and the left. I will continue as I am now, giving everything to the club.”“I had a difficult start to the season for several reasons. I expressed things wrongly and made mistakes.”last_img read more

Schmeichel hopes Leicester defender commits future to the club

Schmeichel hopes Leicester defender commits future to the club

first_imgLeicester City’s Kasper Schmeichel is hoping club teammate Harry Maguire ends speculation surrounding his future and commit to the club.Jamie Vardy, Wilfred Ndidi and now Schmeichel have committed their futures to Leicester City, and the Denmark international hopes defender HarryMaguire will be the next to sign up for the project. The defender was a subject of summer interest from Manchester United after an impressive outing at this summer’s World Cup with England and the Foxes are keen to tie him down at the club by offering him a new contract.Schmeichel, who signed a new five-year deal on Friday, said everyone would love to see Maguire agree a new contract, but no one would put any pressure on him.Harry Maguire, Manchester UnitedLiverpool legend Nicol slams Harry Maguire’s Man United form Andrew Smyth – September 14, 2019 Steve Nicol believes Harry Maguire has made some “horrendous mistakes” recently, and has failed to find his best form since joining Manchester United.“I hope Harry signs but I don’t want to put pressure on anyone,” said Schmeichel, according to LeicesterMercury.“It is up to him, his family and his situation. I am not going to start saying anything about his situation because I don’t know enough about it.”“If he feels it is something he wants to do then we would be delighted, but it is up to him.”City certainly showed signs of their youthful promise during the 2-1 defeat to Liverpool at the King Power Stadium.last_img read more

Martial hoping for an extended Solskjaer stay

Martial hoping for an extended Solskjaer stay

first_imgAnthony Martial has tipped Ole Gunnar Solskjaer to retain the managerial position at Manchester United on a permanent basis.The French midfielder revealed the entire squad is enjoying the reign of the Norwegian boss ahead of their clash with PSG.Martial scored a superb solo goal in United’s 3-0 win over Fulham on Saturday to enter the top four and further extend the unbeaten run under the 45-year-old to 11 games.French connexion ⚡️⚡️⚡️ pic.twitter.com/6q6N13MBFS— Anthony Martial (@AnthonyMartial) December 22, 2018“Well, obviously things are going really well at the moment. We’re really happy to have him here,” the France forward told a news conference ahead of Tuesday’s mouth-watering Champions League showdown against Paris Saint-Germain.“Sure, I hope we can continue with him. The final decision isn’t down to us but certainly, we’re happy he’s here at the moment.”“We’ve got a coach who’s got different intentions, a different approach,” Martial disclosed via FourFourTwo. “We’re trying to do what he wants us to do.“When our new coach came in he had a lot of confidence and a lot of determination. That’s really a boost to us.Harry Maguire, Manchester UnitedLiverpool legend Nicol slams Harry Maguire’s Man United form Andrew Smyth – September 14, 2019 Steve Nicol believes Harry Maguire has made some “horrendous mistakes” recently, and has failed to find his best form since joining Manchester United.“He had a lot of confidence in us and we’re trying to pay him back in kind.“He’s asking me to attack more, that’s my job after all – to make the difference, as it were, to be more decisive“Things are working out well for the other attackers as well. I hope we can continue to be as effective and efficient.”.@AnthonyMartial: “Obviously things are going really well at the moment so we’re happy to have him [Ole] here with us.” #MUFC pic.twitter.com/5pELklKcg0— Manchester United (@ManUtd) February 11, 2019However, Solskjaer feels that there is still room for improvement when it comes to Martial’s finishing.“He’s often said that to me and even previous managers have said that to me,” he added.“I think if I do manage to do that [and] get beyond the defence then I will score more goals.”last_img read more

BROADWAY COMES TO WILMINGTON WHS CATS Broadway Revue Set For October 14

BROADWAY COMES TO WILMINGTON WHS CATS Broadway Revue Set For October 14

first_imgWILMINGTON, MA — Join us for an afternoon of songs – Broadway Style!Wilmington High School (WHS) students will once again delight their audience with selections from hit Broadway shows in this year’s Broadway Revue!Join us on Sunday, October 14 at 3pm in the Wilmington United Methodist Church’s hall (87 Church Street, Wilmington).Admission is $10 for students in advance and $12 at the door. Your admission includes refreshments.Advance ticket price is $10 for all. For advance purchase, mail a check payable to WHS CATS (postmarked no later than 10/5) at PO Box 115, Wilmington, MA 01887. You will receive confirmation and your name will be added to a will call list.100% of the show’s proceeds will benefit the WHS Choral and Theatre Support (CATS) parent group. The WHS CATS mission is to provide scholarships to eligible graduating WHS seniors as well as providing supplementary funds to the groups they support as needed and as they are able.Please come out and support these talented students!(NOTE: The above information is from WHS CATS.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedBROADWAY COMES TO WILMINGTON: WHS CATS Broadway Revue Set For September 23In “Education”BROADWAY COMES TO WILMINGTON: WHS CATS Broadway Revue Set For December 3In “Community”The Wilmington Insider For October 14, 2018In “5 Things To Do Today”last_img read more

Chinese chip giant SMIC to delist from NYSE following Huawei ban

first_imgAnother Chinese tech giant is withdrawing from the US, voluntarily delisting from the New York Stock Exchange. CBS/iStockphoto China’s largest chipmaker plans to delist from the New York Stock Exchange.Semiconductor Manufacturing International Corporation (SMIC) cited limited trading volumes in the US in comparison to the rest of the world as the reason for delisting, according to the South China Morning post on Friday.SMIC also said “the significant administrative burden and costs of maintaining the listing” on the NYSE were reasons for withdrawing.SMIC, which provides integrated circuit foundry and tech services on process nodes from 0.35 micron to 28 nanometer, said it will file the form to delist on June 3, with its last day of trading to be around June 13.While its headquarters are in Shanghai, SMIC also has labs throughout Beijing, Tianjin, Shenzhen, Jiangyin and Italy. It also has offices in the US, Europe, Japan, Taiwan and Hong Kong.The decision to delist follows Chinese technology compatriot Huawei being blacklisted by the US last week, and President Donald Trump signing an executive order essentially banning the tech giant following national security concerns that Huawei had close ties with the Chinese government amid the US-China trade war.SMIC didn’t immediately respond to a request for comment, but told CNBC that its decision to delist was not related to the US-China trade deal.”SMIC has been considering this migration for a long time and it has nothing to do with the trade war and Huawei incident,” a SMIC spokesperson reportedly told CNBC.”The migration requires a long preparation and timing has coincided with the current trade rhetoric, which may lead to misconceptions.” Share your voice Mobile Phones Politics 4:59 Now playing: Watch this: 0center_img Post a comment What is going on between Huawei and the US? Tags Huawei Donald Trumplast_img read more

Reliance Industries hits new 52week high CLSA upgrades stock to Rs 1500

first_imgThe Bombay Stock Exchange in Mumbai on Feb 29, 2016 (representational image).IANSReliance Industries Ltd. (RIL) shares hit a new 52-week high of Rs 1,287 on the Bombay Stock Exchange (BSE) on Friday even as benchmark indices Sensex and Nifty were trading in the red. The RIL stock later shed gains and was trading at Rs 1,268 at around 11.40 am; brokerage CLSA has raised the target price for the stock to Rs 1,500 in a note, reported the Business Today.RIL share price has rallied sharply in the past three months, from Rs 994 on December 5, 2016 to a new high of Rs 1,287, marking a gain of 29.4 percent. The previous 52-week high was Rs 1,256.50 scaled on February 27, 2017.The 30-scrip BSE Sensex was down 84 points to 28,756 while the NSE Nifty was trading at 8,872, down 28 points. Top Sensex losers were HDFC, Asian Paints and ITC.In other corporate news, the Goods and Services Tax (GST) Council decided to peg the peak GST rate at 40 percent to brace for any increase in the rate after the proposed cess is removed. The move does not impact the four tax slabs — 5, 12, 18 and 28 percent.The necessary amendment will be made in the draft GST Bill when the legislation is debated by the Parliament during the second half of the Budget Session that commences on March 9.The trend in Asian stock markets was weak on Friday, reflecting on Indian bourses. “After a weak start, Asian markets were trading lower today as markets took a breather in the U.S. & Europe on Thursday. Post weakness in the Unites States, the Japanese markets today opened almost 0.10 percent lower. The weakness in global markets is very much likely to give domestic markets a lacklustre start as indicated by the SGX Nifty which is trading 0.33 percent down in red,” Geojit BNP Paribas said in a note.Shares of EPC company Larsen & Toubro (L&T) remained almost flat at Rs 1,464 in response to the Karnataka government scrapping the Rs 1,791-crore steel flyover ( from Basaveshwara Circle to Hebbal) project. The company had won the project last October and was awarded the letter of acceptance (LOA).On Thursday, foreign portfolio investors (FPIs) were net buyers of Indian equities worth Rs 123 crore, according to provisional data released by the National Stock Exchange (NSE).The 10-year G-Sec bond ended with a yield of 6.845 percent and the Indian rupee closd at 66.71 to the US dollar on Thursday.last_img read more

Karnataka phone tapping scandal CM Yediyurappa orders probe into case

first_imgTwitter [Representational Image]The Chief Minister of Karnataka BS Yediyurappa has ordered an investigation into the illegal phone tapping scandal in the state after receiving several complaints about the issue.The Karnataka phone tapping scandal is getting murkier after several top shot politicians from the Bharatiya Janata Party (BJP) and government officials alleged that their private conversations were illegally acquired on the approval of the previous Congress-JD(S) coalition.CM Yediyurappa told the state Chief Secretary TM Vijay Bhaskar that an investigation needs to be conducted over the matter to wash out the people responsible for this and hold them accountable for the illegal use of government machinery. Union minister DV Sadananda Gowda has also demanded an investigation over the matter. He said that no one should resort to such means as it is illegal and whoever is responsible for this will be revealed.The probe has been initiated after several leaders of the saffron party including R Ashoka, Tejasvi Surya and former JD(S) leader and disqualified MLA AH Vishwanath requested the state CM to conduct a detailed investigation over the allegations of phone tapping.It is alleged that the former CM HD Kumaraswamy was the man behind the alleged phone tapping. However, he has denied the accusations saying that there was no need for him to tap the phone calls to save the government. He claimed that he would never do such a thing as he has been repeatedly saying that the chief minister’s post is not forever.The phone calls of several politicians from the Congress, JD(S) and the BJP were illegally recorded. Not just politicians, people close to the politicians, journalists covering political stories and senior police officers were also tapped continuously for months until the recent Lok Sabha elections.R Ashoka said that he had complained about the phone tappings about six months ago but then the coalition government headed by HDK had denied it.Bengaluru police commissioner Bhaskar Rao had commissioned a probe into the illegal phone tapping on August 8 after a leaked conversation allegedly from his phone was made public. The alleged clip contained conversation between Rao and another man named Faraz from Delhi, lobbying for his current post with Congress leaders.last_img read more

Demands cant be met at random Hasina

Demands cant be met at random Hasina

first_imgBangladesh prime minister Sheikh Hasina addresses `Shikka Samabesh` (Education Rally), organised by the National University (NU) at Bangabandhu International Conference Center (BICC) in Dhaka on Sunday. Photo: PIDPointing to the street agitation of a particular section of the teachers for various demands, prime minister Sheikh Hasina said on Sunday the government cannot afford to fulfil many demands without plan and budgetary allocation.”We are trying to help every people either in the public or private sector and the government is careful so that none is deprived. But, a government cannot fulfil every demand as it works with a limited budgetary allocation. Everybody should keep this in mind,” she said.The prime minister was addressing “Shikka Samabesh” (education rally) organised by the National University (NU) at Bangabandhu International Conference Centre (BICC) in the capital, reports BSS.Sheikh Hasina said her government has a plan as to which school or college should be nationalised under a policy. “Nationalisation of the educational institution is not possible as per the claim or the wish of any particular section of people.”She said her government has given priority to the education sector as it wants to develop the nation. “So everybody has to perform sincerely and keep their trust in Awami League as the party never deprived anybody and it will not do this in future.”The prime minister said, “None should think that we will fulfil their every demand in the last year of our tenure in power. It’s not the matter of remain in power or not. It’s not our policy.”The prime minister inaugurated and laid foundation stones of 11 educational and infrastructural projects of the NU. She also distributed crest and prize money among the best seven colleges in performance ranking of the university.Sheikh Hasina said her government is trying heart and soul to give highest support to the teachers. After coming to power in 1996 her government had taken many steps for welfare of the teachers prior to placing their demand, she said.last_img
Understanding School Finance Bills In The Special Session

Understanding School Finance Bills In The Special Session

first_imgMarjorie Kamys Cotera for The Texas TribuneGov. Greg Abbott lays out items for a special session at a press conference on June 6, 2017.The Texas House is taking up several measures aimed at reforming the state’s school finance system. It’s one of the issues that prompted Gov. Greg Abbott to call the special session.  What do these measures propose? How are they different from the ones up for consideration during the regular session? And how would they change the ways in which schools are funded? Chandra Villanueva, senior policy analyst with the Center for Public Policy Priorities, lays out the details of the proposed measures. Sharelast_img

Howard University Explores Business and Economic Development in South Africa

Howard University Explores Business and Economic Development in South Africa

first_imgApproximately 100 students participated in the April 15 panel discussion at the Howard University School of Business. The topic of the day, “Business and Economic Development in South Africa: The Mandela Legacy and the 20th Anniversary of Democracy in South African.The event was organized by the Howard University School of Business, in conjunction with the Center for Global Business Studies and the Howard University Republic of South Africa Project. Former president of Bennett College Julianne Malveaux moderated the discussion. The panel included former U.S. ambassador to South Africa Donald Gips; musician and activist Hugh Masekela; partner at Nixon Peabody Kendal Tyre; stakeholder relations manager for the Department of Arts and Culture, Ministry in South Africa Zwelibanzi Ndlovu; and third-year doctoral student at the Department of African Studies Phiwo Mnyandu.After the introductions, each panelist reflected on the changes and challenges of South Africa’s development, reconstruction, and economic opportunities in the 20 years of the country’s democracy.Masekela touched on the economic isolation of the period before the country transitioned from apartheid to democracy. Because of apartheid, countries and organizations around the world halted trade with South Africa. In the United States, organizations like the Congressional Black Caucus played a key role in corporate divestment of South African holding, in an effort to force an end to apartheid and segregation.After apartheid ended in 1994, most sanctions imposed on South Africa by the international community were lifted. “After 1994, I think we freed the business establishment of South Africa that was basically White owned,” said Masekela.Masekela said that to date, people who run the major industries in the country are hanging on to their wealth, refusing to share it with the rural townships. “Nothing has really trickled down to the ordinary, especially African men and women in South Africa,” he said. “There is a very small willingness by the business establishment to include the previously disadvantaged communities.”Looking at the country’s global stance today, Mnyandu said that South Africans are in a limbo between sadness and hopefulness that the country is still making an effort to improve its economic development.Christian Boyd, a freshman international business major from Michigan, asked the panelists if Nigeria’s economic growth, surpassing South Africa as the largest economy, was a good or bad thing for the African continent. Ndlovu said it was good because it was a positive step for the continent as a whole to create a friendly competition between countries in Africa. “If there is another giant, it gives us a challenge to do more as a country,” said Ndlovu.Boyd was impressed with his response. “I got the gist of it because basically he was saying that this was finally something South Africa needed … someone to compete with in terms of growth and their future,” Boyd saidJaelin White, 18, asked Tyre, who deals with franchise companies, manufacturing, and financial services companies on the African continent, how international companies who come into South Africa conserve the cultural aspect of the country.Tyre said franchising is just a way of doing business and 90 percent of the companies franchised are South African. Tyre added that the populous of the country gets to decide what product will succeed and what will fail.last_img read more

Council Member Orange Offers Bill to Get 1 Million Signatures for DC

Council Member Orange Offers Bill to Get 1 Million Signatures for DC

first_imgVincent Orange (D-AtLarge) D.C. Council member (Courtesy Photo)A veteran D.C. Council member seeks to launch a petition drive to get one million people to support making the District of Columbia the 51st state in the union.D.C. Council member Vincent Orange (D-At Large) submitted a “sense of the council” resolution on July 7 called the “‘Statehood or Else’ Signature Campaign of 2015.” Partially using the slogan of the 20th anniversary of the Million Man March – “Justice or Else” – the event will take place on Oct. 10.“The time is now for the District to push for statehood and collecting one million signatures demonstrates that sense of urgency,” Orange said. “It is important to have the signatures by next summer so that the future leadership in the White House makes statehood in the District a priority of their administration.”Orange said he wants to collect one million signatures for a petition supporting D.C. statehood and submit them to the White House, the 535 members of the U.S. Congress, and to the leaders at the 2016 Democratic and Republican conventions.The resolution is legislation that expresses the determination, decision, and direction of the D.C. Council, according to the latest edition of the D.C. Council Handbook. The resolution only has to go through one full reading by the Council and doesn’t have to be approved by the mayor or the U.S. Congress. Orange’s bill will likely be taken up after the D.C. Council’s summer recess, which ends on Sept. 15.D.C. Council members Charles Allen (D-Ward 6), LaRuby May (D-Ward 8), Brandon Todd (D-Ward 8), Brianna Nadeau (D-Ward 1), and Jack Evans (D-Ward 2) are co-sponsoring the legislation. However, while Orange has enough support to pass his bill through the council, he said that more political and governmental leaders need to be on board.“For the campaign’s success, we need Mayor Bowser, all 13 council members, [D.C.] Attorney General Karl Racine, the Chief Financial Officer Jeffrey S. DeWitt, [D.C.]Congresswoman Eleanor Holmes Norton, [D.C.] Senators Paul Strauss and Michael D. Brown, [D.C.] Representative Franklin Garcia, D.C. Vote, D.C. Appleseed and all District residents and citizens of the United States to aggressively support this campaign for D.C. statehood,” Orange said.“The ‘Statehood or Else’ campaign is an opportunity to present a unifying front with the goal of achieving statehood for the District.”Garcia said he supports Orange’s initiative enthusiastically. Garcia, Strauss, and Brown are non-paid elected officials charged with lobbying Congress to grant the District statehood. “It is a good initiative,” Garcia told the AFRO on July 25. “We need to have a national campaign to get statehood and we need to take our message beyond D.C. and its borders.”Garcia said that any effort to highlight the political plight of D.C. residents is worth it. “I was in Rhode Island recently and I explained to an audience that D.C. residents don’t have a vote in Congress and people were shocked to hear that,” he said. “A lot of people don’t know what is going on in D.C. We need to do whatever we can do see that people across the nation are informed about our lack of democracy.”Orange also has the support of Stand Up! for Democracy – Free D.C., a grassroots organization that is pro-D.C. statehood. The organization posted that it “has already planned to work to mobilize and educate visitors for D.C. statehood [on Oct. 10] and will work in coalition with council member Orange and ‘Justice or Else.’However, Orange’s approach does have its critics. Josh Burch, the founder of Neighbors United for Statehood, said on his website, the51st.org, that he supports the spirit of what the council member wants to do, however, some aspects should be changed. “There are many good components in Council member Vincent Orange’s resolution to promote the statehood cause through a multi-media campaign and a petition drive,” Burch said. “The name D.C. Statehood or Else, should be tabled but the basic premise should be preserved, nurtured and developed into something meaningful, impactful and inspiring.”Burch proposes that a march, rally, and a peaceable and non-violent storming of the U.S. Capitol by District residents takes place on April 16 instead of a petition drive.last_img read more

Kappa Alpha Psi Alumni Chapter Celebrates 40th Anniversary

Kappa Alpha Psi Alumni Chapter Celebrates 40th Anniversary

first_imgBy Mark F. Gray, AFRO Staff Writer, mgray@afro.comThe Hyattsville/ Landover alumni chapter of Kappa Alpha Psi Fraternity has been one of the most impactful in its community since its inception in 1979. Their 40th anniversary provided them with an opportunity to laud those who were pillars in the foundation and who have helped it become one of the most influential chapters in the nation during the ceremony at the Hotel at the University of Maryland in College Park.As a chapter that began much like a startup company, Hyattsville/ Landover has leveraged the professional success of its brothers to form the direction of its vision.  It is also a chapter that gained political capital through its four decades of community service.   During its 40 year existence they have remained committed to the youth of Prince George’s County through a “strong organizational foundation that serves both the community and provides programs for youth,” says 18th Chapter Polemarch Michael K. Pitts.The Hyattsville/ Landover alumni chapter of Kappy Alpha Psi Fraternity celebrated its 40th anniversary with a ceremony at the Hotel at the University of Maryland in College Park. (Courtesy Photo)This chapter’s local influence has been noteworthy through various initiatives that began without fanfare and remains behind a silhouette of the many lives it has touched.   High school students in Prince George’s County have benefitted from the chapter’s Guide Right Program, Scholastic Aptitude Test (SAT) preparation and financial aid workshops.   The progressive vision of the chapter has been an example for others throughout the fraternity nationwide.“Our achievements over the last four decades demonstrate how the chapter established a paradigm for community service for fraternities and sororities I Prince George’s County,” says Clarence Jones, the chapter’s historian and chairman of the 40th anniversary of the Awards Planning and Celebration Committee.  “We crossed a mediocre threshold, creating a new threshold and a new threshold of helping others.  These four decades tell the story of how a new era of in community service began to take hold.”During a, sometimes, emotional evening among the brotherhood, laughs and spirits flowed with memories and camaraderie they forged through the years of its volunteer work in Prince George’s County. The chapter’s precedent was acknowledged for how it’s standard has raised the bar for other alumni chapters around the country.  This chapter has been noted for being at the forefront of supporting Kappa Alpha Psi’s national level and has been supportive all around in working with the divine nine. which is the consortium of Black Greek fraternities and sororities.Thomas L. Battles, Jr., the 33rd Grand Polemarch of the national organization, was the keynote speaker and gave credit to this local alumni chapter for evolving from its humble beginning, where it gave men who were interested a chance to pledge to become a member of the vanguard of civic impact.  The men of the Hyattsville/ Landover alumni chapter developed much of the mentoring programming that many national undergraduate and graduate chapters utilize regularly.“This chapter has been at the front of young and old training for leadership,” Battles Jr. said.  “We have always been able to count on the Hyattsville/ Landover alumni chapter to support what we are trying to accomplish through our work in conjunction with the divine nine.”Battles, Jr. also challenged the chapter to continue its leadership in mentoring, especially leading up to the 2020 presidential elections.  While he and the rest of the leaders of the divine nine are moving towards establishing a political action committee to ensure that challenges facing HBCU’s, he was resolute about equipping a new generation with skills necessary to advocate for themselves and to try to change the direction of the country.“We’ve got to teach kids how to tell their story,” Battles, Jr. said.  “Kids are dying these days because they can’t express themselves to authorities.”last_img read more

Astronomers discover bubblelike structure associated with the pulsar PSR J1015−5719

Astronomers discover bubblelike structure associated with the pulsar PSR J1015−5719

first_img(Phys.org)—Astronomers have recently identified a peculiar bubble-like structure associated with an energetic pulsar known as PSR J1015−5719. The newly found feature, designated G283.1−0.59, is most likely a polar wind nebula. The findings were presented June 9 in a paper published on the arXiv pre-print server. More information: Discovery of a Synchrotron Bubble Associated with PSR J1015-5719, arXiv:1706.02978 [astro-ph.HE] arxiv.org/abs/1706.02978AbstractWe report the discovery of a synchrotron nebula, G283.1-0.59, associated with PSR J1015-5719. Radio observations using the Molonglo Observatory Synthesis Telescope and the Australia Telescope Compact Array at 36, 16, 6, and 3 cm reveal a complex morphology. The pulsar is embedded in the “head” of the nebula with fan-shaped diffuse emission. This is connected to a circular bubble of 20″ radius and a collimated tail extending over 1′. Polarization measurements show a highly ordered magnetic field in the nebula. It wraps around the edge of the head and shows an azimuthal configuration near the pulsar, then switches direction quasi-periodically near the bubble and in the tail. Together with the flat radio spectrum observed, we suggest that this system is most plausibly a pulsar wind nebula (PWN), with the head as a bow shock that has a low Mach number and the bubble as a shell expanding in a dense environment. The bubble could act as a magnetic bottle trapping the relativistic particles. A comparison with other bow-shock PWNe with higher Mach numbers shows similar structure and B-field geometry, implying that pulsar velocity may not be the most critical factor in determining the properties of these systems. We also derive analytic expressions for the projected standoff distance and shape of an inclined bow shock. It is found that the projected distance is always larger than the true distance in three dimensions. On the other hand, the projected shape is not sensitive to the inclination after rescaling with the projected standoff distance. © 2017 Phys.org Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Pulsar wind nebulae Citation: Astronomers discover bubble-like structure associated with the pulsar PSR J1015−5719 (2017, June 19) retrieved 18 August 2019 from https://phys.org/news/2017-06-astronomers-bubble-like-pulsar-psr-j10155719.html ATCA radio intensity maps zoomed in at J1015 and the nebula G283.1−0.59 at 16, 6, and 3 cm. The 16 cm image is obtained from the off-pulse phase bins with the pulsar binning data. The crosses mark the pulsar positionand the beam sizes are shown in the lower left. Credit: Ng et al., 2017. Located some 16,600 light years away from the Earth, PSR J1015−5719 is an energetic pulsar with a spin period of 0.14 seconds and an estimated age of about 39,000 years. The pulsar was detected in 2003 by the Parkes Multibeam Pulsar Survey. Although PSR J1015−5719 is located near the gamma-ray source 3EG J1014−5705, so far no pulsed or persistent gamma-ray emission has been found at the pulsar position. Therefore, the possibility of association with this source was excluded by researchers. Moreover, follow-up infrared, optical, and X-ray observations also found no counterparts to this pulsar.Now, a team of astronomers led by C.-Y. Ng of the University of Hong Kong presents the results of new radio observations of PSR J1015−5719, which reveal an interesting structure associated with this pulsar. The observational campaign was conducted using the Molonglo Observatory Synthesis Telescope (MOST) and the Australia Telescope Compact Array (ATCA), both located in Australia. The new data allowed the researchers to reveal a nebula consisting of a diffuse head, a circular bubble, and a collimated tail.”We report the discovery of a synchrotron nebula, G283.1−0.59, associated with PSR J1015−5719. Radio observations using the Molonglo Observatory Synthesis Telescope and the Australia Telescope Compact Array at 36, 16, 6, and 3 cm reveal a complex morphology. The pulsar is embedded in the ‘head’ of the nebula with fan-shaped diffuse emission. This is connected to a circular bubble of 20″ radius and a collimated tail extending over 1′,” the scientists wrote in the paper.According to the authors of the study, G283.1−0.59 is most likely a bow-shock pulsar wind nebula (PWN). PWNe are characterized by broadband synchrotron radiation from radio to X-ray bands when they are formed as a result of interaction of pulsar wind with the ambient medium. The morphology of bow-shock PWNe includes a long collimated tail with a small bow-shock standoff distance.The team revealed that morphology of G283.1−0.59’s head resembles the shape of a classical bow shock. The results also suggest a projected stand-off distance of about 20″. Therefore, the researchers argue that the morphology of the newly discovered nebula is similar to that of other PWNe.The hypothesis that G283.1−0.59 is associated with and thus powered by PSR J1015−5719 is based on the fact that the nebula is very close in projection to the pulsar.”We suggest that this is a newly identified bow-shock PWN associated with J1015. (…) Given its peculiar properties, a chance coincidence seems very unlikely,” the paper reads.The astronomers concluded that G283.1−0.59 is an interesting rare example of a slow moving bow-shock PWN, in which the pulsar spin axis misaligns with the proper motion direction.last_img read more

Weaving a continuity of expressions

Weaving a continuity of expressions

first_imgPratha Parv – a festival of folk, tribal and traditional cultural expressions of India is being presented by Sangeet Natak Akademi, a national academy of music, dance and drama and an autonomous body under the Ministry of Culture, Government of India.In a country as vast and layered with history, antiquity and diversity, it is the realm of performing arts in which a deep connection of various genres of art or skill can be seen weaving a continuity of expressions.  Also Read – Add new books to your shelfTraditional cultural expressions also called ‘expressions of folklore’ may include music, dance, art, designs, names, signs and symbols, performances, ceremonies, architectural forms, handicrafts and narratives, or many other artistic or cultural expressions including the folk and tribal art. These, which essentially form parts of the identity and heritage of a traditional or indigenous community, are passed down from generation to generation, and are integral to the cultural and social identities of indigenous and local communities. They transmit core values and beliefs. And primarily, these notions are constantly developing and being recreated within the community ie the practitioners and connoisseurs and passed on to new generations as future protectors of the shared legacy. Also Read – Over 2 hours screen time daily will make your kids impulsiveThe festival comprises presentations of diverse forms of performing arts, film screenings sourced from the meticulously cultivated archives of the Akademi exhibition and dissemination of various musical instruments, folk and traditional, from different states of the country (primarily North-East, Odisha, Kerala and Uttarakhand). The programme also includes interactive session with artists who will share their traditional methodologies and other related aspects that may bring forth the tangible and intangible aspects to incorporate verbal expressions or symbols (stories, epics, legends, tales, riddles), musical expressions (songs, instrumental music), expressions by action (dance form, play, ritual), tangible expressions (drawings, designs, paintings, body art, carvings, woodwork, metal work, jewellery, glassware, textiles, costumes) and  intangible expressions reflecting traditional forms of thought and architectural forms. The festival is an opportunity to bringing into limelight and assimilating a variety of cultural aspects of the country, as defined as North, South, East, and West and the resplendent North-East. Each day of the festival is based on this cultural classification, which aims to enhance and safeguard the inherent plurality of the cultural identity that this country so strongly identifies with.last_img read more

Reinforcement learning model optimizes brain cancer treatment reduces dosing cycles and improves

Reinforcement learning model optimizes brain cancer treatment reduces dosing cycles and improves

first_imgResearchers at MIT have come up with an intriguing approach to combat ‘Glioblastoma’- a malignant tumor of the brain/spinal cord- using machine learning techniques. By reducing the toxic chemotherapy and radiotherapy that is involved in treating this cancer, the researchers aim to improve the quality of life for patients, while also reducing the various side effects caused by the former using Reinforcement learning techniques. While the prognosis for adults is no more than 5 years, medical professionals try to shrink the tumor by administering drug doses in safe amounts. However, the pharmaceuticals are so strong that patients end up suffering from their side effects. Enter Machine Learning and Artificial Intelligence to save the day. While it’s no hidden truth that machine learning is being incorporated into healthcare on a huge scale, the MIT researchers have taken this to the next level. Using Reinforcement Learning as the Big Idea to train the model Media Lab researcher Gregory Yauney will be presenting a paper next week at the 2018 Machine Learning for Healthcare conference at Stanford University. This paper details how the MIT Media Lab researchers have come up with a model that could make dosing cycles less toxic but still effective. Incorporating a “self-learning” machine-learning technique, the model studies treatment regimens being used presently, and iteratively changes the measurements. In the end, it finds an ideal treatment design suited to the patient. This has proven to reduce the tumor sizes to a degree almost identical to that of original medical regimens. The model simulated trials of 50 patients and designed treatments that either reduced dosages to twice a year or skipped them all together. This was done keeping in mind that the model has to shrink the size of the tumor but at the same time ensuring that reduced dosages did not lead to harmful side effects. The model is designed to used reinforced learning (RL)- that comprises artificially intelligent “agents” that complete “actions” in an unpredictable, complex environment to reach the desired outcome. The model’s agent goes through traditionally administered regimens. It uses a combination of the drugs temozolomide (TMZ) and procarbazine, lomustine, and vincristine (PVC), administered to the patients  over weeks or months. These regimens are based on protocols that have been used clinically for ages and are based on both, animal testing and various clinical tests and scenarios. The protocols are then used by Oncologists to predict how many doses the patients have to be administered based on weight. As the model explores the regimen, it decides on one of the two actions- Initiate a dose Withhold a dose If it does administer a dose, it has to make the decision if the patient needs the entire dose, or only a portion. After a decision is taken, the model checks with another clinical model to see if the tumor’s size has changed or if it’s still the same. If the tumor’s size has reduced, the model receives a reward else it is penalised. Rewards and penalties essentially are positive and negative numbers, say +1 or – 1. The researchers also had to ensure that the model does not over-dose or give out the maximum number of doses to reduce the mean diameter of the tumor. Therefore, the model is programmed in such a way that whenever it chooses to administer all full doses, it gets penalized. Thus the model is forced to administer fewer, smaller doses. Patik Shah, a principal investigator at the Media Lab who supervised this research, further stresses on the fact that, as compared to traditional RL models that work toward a single outcome, such as winning a game, and take any and all actions that maximize that outcome, the model implemented by the MIT researchers is a  “unorthodox RL model that weighs potential negative consequences of actions (doses) against an outcome (tumor reduction)” The model is strikingly wired to find a dose that does not necessarily maximize tumor reduction, but also establishes a perfect balance between maximum tumor reduction and low toxicity for the patients. The training and testing methodology used The model was trained on 50 simulated patients –  randomly selected from a large database of glioblastoma patients. These patients had previously undergone traditional treatments. The model conducted about 20,000 trial-and-error test runs for every patient. Once training was complete, the model understood the parameters for optimal regimens. The model was then tested on 50 new simulated patients and used the above-learned parameters to formulate new regimens based on various constraints that the researchers provided. The models treatment regimen was compared to the results of a conventional regimen using both TMZ and PVC. The outcome obtained was practically similar to the results obtained after the human counterparts administered treatments. The model was also able to treat each patient individually, as well as in a single cohort, and achieved similar results (medical data for each patient was available to the researchers). In short, the model has helped to generate precision medicine-based treatments by conducting one-person trials using unorthodox machine-learning architectures.Nicholas J. Schork, a professor and director of human biology at the J. Craig Venter Institute, and an expert in clinical trial design explains  “Humans don’t have the in-depth perception that a machine looking at tons of data has, so the human process is slow, tedious, and inexact,” he further adds  “Here, you’re just letting a computer look for patterns in the data, which would take forever for a human to sift through, and use those patterns to find optimal doses.” To sum it all up,  Machine learning is again proving to be an essential asset in the medical field- helping both researchers as well as patients to view medical treatments in an all new perspective. If you would like to know more about the progress done so far, head over to MIIT news. Read Next 23andMe shares 5mn client genetic data with GSK for drug target discovery Machine learning for genomics is bridging the gap between research and clinical trials 6 use cases of Machine Learning in Healthcarelast_img read more

The Dress Code for This New Restaurant Is Your Birthday Suit

first_img Add to Queue Opinions expressed by Entrepreneur contributors are their own. Niche marketing Twin brothers in Paris left the insurance business to open a restaurant catering to nude vegans. Contributor President of The Marks Group Image credit: O’naturel | Facebook Next Article Apply Now » The only list that measures privately-held company performance across multiple dimensions—not just revenue. –shares 3 min read Gene Marks 2019 Entrepreneur 360 List November 8, 2017 The Dress Code for This New Restaurant Is Your Birthday Suit If you’ve ever had the desire to eat an entire meal in public and be completely naked at the same time well…now’s your chance. Just go to Paris and make a reservation at O’naturel.Yes, that’s the actual name and at the 40-seat O’naturel, which opened its doors last week, customers are asked to leave their clothes in the cloakroom and proceed – in all their splendidness – to dine with other clothe-less patrons. The “bistronomic” menu starts around € 39 (about $45) and features vegan dishes, whitch are popular among naturists, and of course a great wine selection. This is Paris, let’s not forget.Related: Dear Entrepreneurs: Small Is Still BeautifulDon’t worry, health officials, the staff are clothed, patrons wear slippers and the seats have disposable covers.According to two reports last week here and here in Le Parisian, would-be voyeurs on the street won’t get a peep show. The establishment sports a “neutral” front, with a heavy blackout curtain and other screens covering the main windows. The entrance is designed to prevent anyone from seeing inside, even when the doors are opened. The establishment received a hearty thumbs up from members of the Association des Naturists de Paris, who were invited to be the very first diners.Related: 9 Startups Changing the Fabric of FashionThe French, being French, aren’t ruffled. In fact, residents in the restaurant’s neighborhood are mostly indifferent to its uniqueness. “When we learned what was going to be here, obviously it made us laugh. Especially since there is a nursery next door,” one resident who lives above the restaurant said. “But it does not bother me.”Even though it’s early days, things seem to be going pretty well for Mike and Stéphane Saada, the twin-brothers who own the restaurant. The Saada twins are ex-insurance industry executives and, unsurprisingly, ardent naturists. The restaurateurs are hoping to tap into the two-million strong naturist community in France. “We have already had quite a few reservations on the Internet,” they said, adding the comments coming in on their website are “very nice.”Related: 7 Steps to Defining Your Niche MarketLots of people open up restaurants and it’s no secret that many of them fail. It’s a hard and competitive business. Which is why a potential road to success is picking a demographic — whether it’s vegans, naked people or even lovers of the Golden Girls — and (of course) serving up good food. In this highly specialized world, many smart business owners I know are zeroing in on a targeted industry and becoming excellent at a particular skill to stand out and profit. So why not excellent food that caters to the community of French naturists?Oh, and the best thing about O’naturel? Well, in my opinion, it’s that no matter how high the bill is, you’ll never feel like you’ve lost your shirt.last_img read more

SocketLabs Names New Chief Revenue Officer to Drive Next Wave of Growth

first_img crmemail delivery solutionsKeith HontzMarketing Technology NewsNewsSAPSocketLabs Previous ArticleValassis Research: Digital Dads Crave Shopping Convenience and Cross-Channel DealsNext ArticleComcast Business Earns Seven 2019 American Business Awards Including Recognition as Most Innovative Company of the Year SocketLabs Names New Chief Revenue Officer to Drive Next Wave of Growth in Email Delivery Market PRNewswireJune 10, 2019, 1:13 pmJune 10, 2019 SocketLabs, an industry-leading provider of highly scalable email delivery solutions that drive customer engagement and growth, is pleased to announce the appointment of Keith Hontz as Chief Revenue Officer.Keith Hontz, top performer over two decades with SAP, joins @socketlabs as its first chief revenue officer to drive next wave of growth in email delivery marketHontz joins SocketLabs from SAP America, Inc., where he was Global Vice President of SAP Industries. With over two decades of experience as a top performer in roles spanning sales, business development, product management, presales and consulting, Hontz brings an extensive background in customer experience solutions and engaging with enterprise and mid-market accounts. Most recently at SAP, he served as an executive advisor to tech start-ups at the SAP.iO Foundry in New York City, imparting his enterprise selling experience and entrepreneurial spirit.As a dynamic software executive with a proven track record of success, Hontz is excited to introduce SocketLabs’ unique communication technology to an expansive network of enterprises, integration partners and ISVs. He will be overseeing the revenue engine for SocketLabs, including new customer acquisition, sales functions and strategic partnerships, – and helping to define the company’s go-to-market strategy. Hontz will also bring a new focus to key industries driving value for line-of-business executives across IT, Marketing, Sales, Service, Commerce, HR, Operations and Procurement as well as support for leading CRM vendors and application developers.Marketing Technology News: Agency Veteran Joao Machado Joins as Sabio’s SVP of Product Marketing“Keith’s track record of sales success is hard to match,” said John Alessi, SocketLabs Founder and President. “We are excited to welcome a leader of his caliber to our team and look forward to expanding our business under his guidance as our first Chief Revenue Officer.”Founded in 2007, SocketLabs has been helping organizations around the globe, across multiple industries, deliver billions of critical emails to their prospects, customers, clients and members. The company’s founders are email software specialists who began with a vision of providing the most advanced and specialized email delivery technology in a ubiquitous, cloud-based solution.Today, SocketLabs powers email delivery for some of the world’s leading brands such as ADP, Advocare, Aston Martin, APSIS, Cisco, Customer Thermometer, Deluxe, Diebold, Honeywell, IBM, MaritzCX, Ohio State University, Panera Bread, Penn State University, ProntoForms, ReMax, Siemens, TeamSupport and Warner Brothers. The SocketLabs data processing addendum enables customers to maintain compliance with GDPR.In 2018, Philadelphia-based entrepreneur and philanthropist, Chase Lenfest, purchased a controlling interest in SocketLabs.Marketing Technology News: Vidyard Expands Offering to Bring Personalized Video App to Any Sales Professional, No Matter How They Work“We see great growth potential in SocketLabs, in part because the company’s technology has already generated broad adoption and a long track record of customer success with very minimal outbound sales efforts,” said Lenfest. “Keith will be an extraordinary addition to our team as we embark on our next wave of growth with world-class companies across the globe.”“I look forward to my new role at SocketLabs, leveraging my background in enterprise software and customer experience to drive our business forward. SocketLabs is an innovative tech company with a winning team that’s poised for massive growth,” said Hontz. “The business impact of email continues to grow as a vital communication channel for enabling customer engagement, yet over 20 percent of commercial email worldwide fails to reach the intended recipient’s inbox, either getting diverted to spam folders or blocked altogether. It’s a professional privilege to support SocketLabs’ vision of helping our clients break through these barriers and enabling successful email communications that matter most for their business. Our future ahead is bright and I’m looking forward to growing the business together with our customers.”Marketing Technology News: AdQuick.com Releases Campaign Genius, so Marketers can Plan and Optimize Out of Home (OOH) Advertising Campaigns in Minuteslast_img read more

TCALM Phase 2 clinical study results offer hope for essential tremor patients

first_img Source:http://www.cavionpharma.com/ The TETRAS Activities of Daily Living (TETRAS-ADL) scale, a measure of tremor impact on daily activities (p=0.049) The Clinician Global Impression of Improvement (CGI-I), a measurement of physician-reported global improvement (p=0.001) The TETRAS Total Score (TETRAS ADL + TETRAS-PS rated by the study Investigators, p=0.029) The Goal Attainment Scale (GAS), a measure of progress toward patient-selected goals (such as dressing oneself, writing a sentence, or drinking out of a cup) (p=0.034) Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 7 2018Cavion, Inc., a leading clinical stage biotechnology company committed to developing novel therapeutics for people with neurological diseases, today announced promising results of the T-CALM Phase 2 clinical trial of its first-in-class T-type calcium channel modulator CX-8998 in essential tremor. The company plans to present results from this proof-of-concept study as a late-breaking poster on Monday, October 8 at the International Congress of Parkinson’s Disease and Movement Disorders® in Hong Kong.Multiple secondary and exploratory endpoints collectively showed that treatment with CX-8998 10mg twice daily resulted in statistically significant improvement versus placebo in activities of daily living and patient-reported and clinical outcome measures, despite the study’s primary endpoint being missed. In the study, CX-8998 demonstrated a favorable safety and tolerability profile, with patients in the drug treatment arm reporting higher levels of satisfaction with tremor control medication compared to patients on placebo.”After decades without new effective drug therapy options, we believe that the neurostabilizing effects of CX-8998 provide hope for essential tremor patients,” said Spyros Papapetropoulos, MD, PhD, Cavion’s Executive Vice President of Research & Development and Chief Medical Officer. “The data are particularly compelling given that about two-thirds of patients in the study were on standard of care treatment and significant improvement was achieved with CX-8998 on several measures in a study lasting just one month.””Essential tremor is a challenge to treat, and patients often do not respond favorably to the existing medications, many of which have been available for decades,” said Karl Kieburtz, MD, MPH, Professor of Neurology at the University of Rochester Medical Center. “Cavion’s CX-8998 has a novel mechanism of action that may provide substantive improvement, and it could be an important therapeutic contribution above and beyond what we currently have for essential tremor. I look forward to its clinical progress and further investigation. Better medications are needed to treat this common and disabling movement disorder.”T-CALM was a 28-day, double-blind, placebo-controlled Phase 2 proof-of-concept clinical trial in 95 patients with moderate to severe essential tremor, conducted at 25 sites across the United States. Patients were randomized to receive either placebo or CX-8998 titrated up to 10mg dosed twice daily (BID). A majority of subjects (64 percent) added study drug to their existing standard of care anti-tremor medication.The primary study endpoint using remote video rating of the Tremor Research Group Essential Tremor Rating Assessment Scale – Performance Subscale (TETRAS-PS), a measure of tremor severity, did not meet significance at Day 28 (p=0.696). In contrast, the same TETRAS-PS scale rated by the study investigators who observed the patients in person resulted in a significant improvement in tremor severity at Day 28 for the CX-8998 treated group compared to placebo (p=0.027). Independent analysis of the video rating process uncovered unexpected complications in implementation. Cavion is working closely with the scientific community to enhance central video rating for use in interventional studies.Related StoriesOxidative stress could play key role in the spreading of aberrant proteins in Parkinson’s diseaseOlympus Europe and Cytosurge join hands to accelerate drug development, single cell researchResearchers challenge conventional understanding of cause of Parkinson’sMultiple secondary and exploratory endpoints collectively showed statistical significance, with benefits after 28 days of treatment in patients receiving CX-8998 10mg twice daily (BID) compared to placebo in the following scales:center_img In addition, the Patient Global Impression of Change (PGI-C), a measure of patient-reported improvement, trended towards significance favoring CX-8998 (p=0.089). Kinesia One, an algorithm-based digital measure developed for Parkinson’s disease, failed to detect a treatment difference in Essential Tremor patients. Additional analyses, including patient satisfaction with control by anti-tremor medication and traditional and digital spirography, support a treatment benefit with CX-8998. The drug showed a favorable safety and tolerability profile, with the majority of adverse events mild to moderate, transient and non-recurring. No major differences between CX-8998 and placebo were observed in laboratory values, vital signs or electrocardiography.In addition to the T-CALM study for essential tremor, CX-8998 is currently being studied in T-WAVE, a multi-center Phase 2 clinical trial for generalized epilepsy with absence seizures. “The body of evidence supporting our ground-breaking approach is rapidly expanding,” said Andrew Krouse, President and CEO of Cavion. “Our pipeline of T-type calcium channel therapies extends beyond tremor to other neurological diseases that share a common pathophysiology. We look forward to initiating a Phase 3 study in tremor soon.”​last_img read more

Scientists identify skeleton key for congenital kidney disease research

first_img Source:http://ewww.kumamoto-u.ac.jp/en/ Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 31 2018Scientists in Japan have found a ‘skeleton key’ for congenital kidney disease research. Using iPS cells generated from the skin cells of a patient with a nephrin mutation, Kumamoto University scientists have successfully developed kidney tissue that exhibits the early stages of congenital kidney disease. The protein nephrin is a constituent of the kidney filtration membrane and abnormalities of this protein are commonly found in other types of kidney diseases. The results of this work are expected to unlock several doors in future kidney disease research.The kidneys are organs that filter out and discharge waste products from the blood. During this process, proteins in the blood should not leak into the urine. The membrane responsible for this filtration is part of the glomerular podocyte and nephrin is its main constituent. If there is a genetic mutation affecting the nephrin, a large amount of protein in the blood can leak into the urine resulting in congenital nephrotic syndrome. The treatment of this syndrome is radical and difficult, and the absence of a technique to artificially reproduce a mutated filtration membrane has been a bottleneck in research progress.In 2014, this Kumamoto University research group succeeded in the extremely difficult task of producing artificial kidney tissue in vitro from human iPS cells–a world first. And in 2016, they found that glomerular podocytes derived from iPS cells strongly express nephrin, that the human glomeruli readily connects with mouse blood vessels, and that induced podocytes continue to mature after transplantation into mice. With this knowledge, they applied their techniques to iPS cells derived from a single patient for their most recent project.Related StoriesNew imaging probe allows earlier detection of acute kidney failureLow dose of endotoxin could have protective effect on men at risk of acute kidney injuryBordeaux University Hospital uses 3D printing to improve kidney tumor removal surgeryFirst, they established iPS cells from the skin cells of a patient with congenital nephrotic syndrome having a single nephrin mutation. When they induced kidney tissue from these iPS cells in vitro, they found that nephrin, which should exist on the surface of the glomerular podocyte, remained inside the cell, and that almost no filtration membrane precursor could develop. When podocyte maturation was performed by transplantation into mice, nephrin, which typically moves toward the blood vessel side of normal podocytes again remained inside the patient-derived cells. In other words, the initial pathology of this congenital kidney disease was reproduced by the iPS cells derived from the diseased patient.Furthermore, when the nephrin mutation in patient-derived iPS cells were repaired and then induced into kidney tissue, the abnormalities were normalized. Put simply, the researchers found that this single mutation is the cause of the disease, and showed that it could possibly be treated by repairing the mutation.”Because we can now reproduce the pathology of congenital nephrotic syndrome, it should be much easier to explore therapeutic drugs using this podocyte,” said project leader Professor Ryuichi Nishinakamura. “Even when kidney disease develops in adults, it often begins with abnormal quantities of protein in the urine. It is believed that this is often caused by trouble in the nephrin protein of the filtration membrane. If a medication is discovered that controls nephrin protein, there is a strong possibility that it will be highly effective for kidney disease. What we have achieved here is a big step towards the development of drugs that act on podocytes and reduce proteinuria.”last_img read more