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Hereditary Breast Cancer Are You at Risk

Hereditary Breast Cancer Are You at Risk

first_img Related Items: Facebook Twitter Google+LinkedInPinterestWhatsApp Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, TCI, November 8, 2016 – For about five to ten percent of women diagnosed with breast cancer, hereditary factors are the root cause. In fact, having a first-degree (mother, sister, daughter) relative with breast cancer, increases the potential that you are carrying a mutated breast cancer gene.   And, women who inherit a gene mutation have a much higher risk of developing breast cancer.A gene can often harbor an abnormality that changes how the cell works or responds to its environment. According to Sara Carroll, genetic counselor at Cleveland Clinic Florida, “the most common causes of hereditary breast cancer include mutations in the BRCA 1 and BRCA 2 gene.”  There are other hereditary causes of breast cancer, but these are the most prevalent. These genes can be inherited from either parent.BRCA genes help to correct DNA damage. In people with a mutation in BRCA1 or BRCA2, the ability to repair damage is impaired and can sometimes lead to breast cancer.  This suggests an estimated 87% lifetime risk of developing breast cancer, which begins to steeply rise at the age of 30. The risk of developing breast cancer by the age of 50 is approximately 50%.There are several factors that can suggest the possibility that hereditary breast cancer runs in your family. You should be concerned if:There is both breast and ovarian cancer in your family.Diagnosis of breast cancer has occurred before age 50.Diagnosis of bilateral breast cancer (cancer in both breasts).Ask about genetic counseling if you are concerned, or call for a risk assessment appointment if you are unsure. High-risk women can be tested to screen for mutations in the BRCA genes. “Genetic testing can be beneficial in determining whether a cancer diagnosis was random or the result of an inherited mutation,” says Ms. Carroll.  This is valuable information, as there may also be an increased risk for other cancers as well.  Your family members will also benefit from discovering whether a hereditary risk exists.At the genetic counseling visit, a personal and detailed family medical history will be obtained.  Depending what your hereditary risk factors are, we can determine whether or not genetic testing is appropriate, and which genetic changes to assess.  Genetic testing involves a blood test, and the results are typically known in a few weeks. Hereditary risk assessment and genetic testing have become tools in the personalization of breast cancer treatment, by providing a basic understanding of the structure and function of genes at a molecular level. This knowledge allows the best clinical management to be determined.  In some instances, additional breast cancer risk management options may be necessary.  Tell your doctor about your family history of breast cancer and discuss whether that history might support the consideration of changes to your care.The Breast Center at Cleveland Clinic Florida is fully accredited by the National Accreditation Program for Breast Centers (NAPBC), a designation given to centers that are committed to providing the highest quality breast care. The breast cancer team provides the most up-to-date information on the genetic components of breast cancer, and offers predictive testing for family members who may have inherited a specific genetic mutation.“Understanding the increased genetic risk enables you to evaluate your options in advance.  Working with our breast cancer care team, you can create a personalized plan, designed to prevent or detect cancer at an earlier and more treatable stage,” states Ms. Carroll.  Women can be empowered to make important health decisions, armed with the knowledge of their genetic breast cancer risk.last_img read more

Aberdeen Proving Ground Support Group Gains New Chief

first_img Dan Cohen AUTHOR Harford County, Md., has hired Daniel Whipp, a Marine Corps veteran, to lead the Chesapeake Science & Security Corridor (CSSC), a regional consortium dedicated to sustaining Aberdeen Proving Ground.CSSC has led growth planning efforts in northeastern Maryland since the 2005 BRAC round and has received more than $10 million in funding from DOD’s Office of Economic Adjustment. The consortium is an arm of the Harford County Office of Economic Development; its 52 government, industry and academia members strive to improve the region’s economic vitality.The group has conducted more than 25 studies, covering topics such as curriculum needs, research park feasibility and commuter services. A joint land use study is currently under way with Harford, Cecil and Kent counties, the cities of Aberdeen and Havre de Grace, and Aberdeen Proving Ground.“CSSC is a critical entity in terms of communication and collaboration across our region for our defense community,” County Executive Barry Glassman said in a press release. “Although we strive for a diversified economy, we recognize the vital role DOD and the related contracting community contributes as an economic engine.”While serving in the Marine Corps, Whipp completed Marine officer leadership and artillery officers’ courses, and completed an operational deployment in support of Operation Enduring Freedom in Helmand Province, Afghanistan. He is a 2014 Loyola University MBA graduate and worked as a problem solver area manager at Amazon.last_img read more

Wilmington Little Leagues Latest Game Summaries

Wilmington Little Leagues Latest Game Summaries

first_imgWILMINGTON, MA — Below are a couple of recent Wilmington Little League game summaries:AAA: Astros vs. Pirates on Saturday, May 4, 2019 at Boutwell FieldAnother hard-fought game was waged between the Pirates and the Astros. After leading for most of the game, the Pirates were unable to hold off the tenacious Astros, falling 10 to 8 in 5 innings. Mickey Moroney was stellar for the Pirates in his first game on the mound pitching two solid innings. With some timely hitting, the Pirates held leads of 4 to 1 and 5 to 3 into the middle innings. The Astros’ starter Dylan Costantiello struck out one and made a nice play in the field during his inning of work. Tony Cummings then pitched three innings, striking out seven and making two plays of his own. Finally, Cael Considine baffled the Pirates’ hitters in the last inning, striking out two. Solid fielding is emerging as one of the Astros’ strengths. Considine’s two putouts at first base, Aidan Raposa’s great play at third for an unassisted putout, and Owen Wills snaring a sharp grounder at third holding the Pirates’ batter to a single were three examples. Every Astro found his way on base during the game led by Kevin Pruslin, John Roofe, Patrick Moriarty, and Jake Gryglik who were each on base three times. Roofe continued his hot hitting with a single and a booming double. Moriarty ripped two singles as the other player with a two-hit afternoon. Raposa launched a screaming single up the middle in the third inning and Pruslin, Cummings, Considine, Andrew Santo, and Kyle Price added singles of their own. Costantiello, Connor Jamieson, Gryglik, and Wills were among those who displayed their keen batting eyes working walks and Gryglik again showed his blazing speed with a stolen base. The final rally included clutch hits and walks by Roofe, Santo, Raposa, Jamieson, and then the game-winning single by Moriarty scoring Santo. Overall, the Pirates and Astros left it all out on the field and had a great time doing so!Single A: Ray vs. Pirates on Monday, May 6, 2019 at Boutwell FieldThe Pirates and Rays played a close game. The Rays made several great plays and had strong pitching performances from Michael Crowley, Tommy Roofe, and Ryan Doherty. Defense was impressive tonight featuring great plays by Brendan Cyr and an impressive inning as catcher by Sean Witalisz. The bats were alive early on with some big hits by Benji Hebert, Alex Sullivan, Chris Gattineri, Jackson Childs, and Cameron White. The Pirates were led on the mound by Zach Maiella, Ryan Biggins, and Bart Zaino, while Joshua Lopez and Colby O’Brien were strong behind the plate. Jack Jamieson had a great defensive game at first base as well. The bats were on fire early, with Nico McCollem starting things with a leadoff hit. Bradley Stephen, Sam Beaudoin, and Sean Theodos joined in with their own timely hits, and Ben Sawyer showed off his speed running the bases.(NOTE: Summaries provided by the Wilmington Little League.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedWilmington Little League’s Latest Game SummariesIn “Sports”Wilmington Little League’s Latest Game SummariesIn “Sports”Wilmington Little League’s Latest Game SummariesIn “Sports”last_img read more

French Physicists Calculate Mean First Passage Time

French Physicists Calculate Mean First Passage Time

first_img Physicists at the University of Pierre & Marie Curie Physiques Laboratory in Paris have developed a general theory that allows accurate evaluation of the mean First Passage Time, (FTP) in complex media. The lead scientist, S. Condamin, O. Benichou, V. Trejedor, and R. Voituriez in Paris combined efforts with J. Klafter of Tel Aviv University in Israel to accurately assess FTP in complex situations, heretofore the calculation was based on one dimensional geometries or to higher spatial dimensions in homogeneous media.The importance of calculating FTP can best be understood as pondering the question, “How long does it take a random walker to reach a given target.” The FTP is critical in assessing and predicting spreading of disease, neuron firing dynamics, and transport of disordered media. Over the past decades scientists from various disciplines have studied and researched the predictability of FTP .The title of the Letter report is entitled, First Passage Times in Complex Scale Invariant Media was published in Nature 450, at pages 77-80 on November 1, 2007. The scientists state that they have developed an analytical approach that provides a universal scaling dependence of the mean FTP on both the volume of the confining domain and the source-target distance. The scientists have performed various numerical simulation tests for representative models of disordered media, fractals, anomalous diffusion, and scale-free networks. The results of their research is applicable to a broad range of stochastic processes characterized by length, scale invariant properties. Further information and request for materials may be directed to Dr. O. Benichou at benichou (at)lptmc.jussieu.fr. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. First Passage Time, (FTP) can best be understood by pondering the question, “How long does it take a random walker to reach a given target?” The FTP is key to predicting the spread of disease, neuron firing dyanmics and more. Predicting FTP in Complex Models Citation: French Physicists Calculate Mean First Passage Time (2007, November 2) retrieved 18 August 2019 from https://phys.org/news/2007-11-french-physicists-passage.htmllast_img read more