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2012 Vawdon Cup Results

first_imgCongratulations to the winners of their respective divisions in the 2012 New South Wales Touch Association (NSWTA) Vawdon Cup finals. Men’s Open Penrith Panthers 7 defeated Parramatta Eels 6 (drop-off)Women’s Open Eastern Suburbs Roosters 7 defeated Wollongong Devils 5Mixed Open Eastern Suburbs Roosters 6 defeated Wests Magpies 4Men’s Division OneHornsby Lions 6 defeated Wollongong Devils 1Women’s Division OneCentral Coast Dolphins 5 defeated Northern Suburbs Bears 4Men’s Division TwoEastern Suburbs Roosters 8 defeated Wests Magpies 6Women’s Division TwoLiverpool Lightning 2 defeated Hills Hornets 2Men’s Division ThreeRyde Eastwood Hawks 8 defeated Penrith Panthers 4Men’s Masters (played on the 19th October)Balmain Tigers 9 defeated Penrith Panthers 0Men’s Seniors (played on the 19th October)Wests Magpies 6 defeated Canterbury Bulldogs 5Related LinksVawdon Cup Resultslast_img read more

Former Michigan Star Taylor Lewan Trolls Former Michigan State Star Jack Conklin On Instagram

first_imgJack Conklin's Michigan State jersey seen in the Tennessee Titans locker room.Instagram/Taylor LewanMichigan State has owned Michigan on the gridiron in recent history, winning seven of the last eight matchups between the two programs. But one prominent former Wolverine is tired of living in the past, and Wednesday he had a little fun at the expense of his new Tennessee Titans teammate – a former Spartan.Former Michigan offensive tackle Taylor Lewan, who was drafted 11th overall back in 2014, apparently wasn’t a fan of what former Michigan State offensive tackle Jack Conklin, who was drafted eighth overall this year, had hanging in his locker room. Lewan, after seeing Conklin’s Spartans jersey, playfully told him to “grow up” on Instagram. He added a “Go Blue” for fun too. Lewan and Conklin are both expected to play prominent roles for the Titans this year.last_img read more

On Maestro Michie Mee and mix tapes Torontos hiphop archive takes shape

first_imgAs he looks around at the upscale recording studio he marvels at a little-known fact. Until recently, the university had no idea that former student Ron Nelson became the “godfather” of Toronto hip hop while sitting in a much more modest chair in a Ryerson community radio station. Mark Campbell is sitting in a bright pink chair in the Allan Slaight Radio Institute at Ryerson, recounting his younger days as a member of an east-end hip-hop sound crew and later, a DJ on a community radio station. Twitter LEAVE A REPLY Cancel replyLog in to leave a comment Advertisement Campbell, 38, began documenting Toronto’s vibrant hip-hop scene in 2009 after discovering during research for a book that little had been written about it. Advertisement He has organized live events so that artists and industry insiders can tell their stories and share memorabilia. The historical material is being compiled online in the Northside Hip Hop Archive, a website that hosts a collection of audio, images and accounts — beginning in the late ’80s — that is funded by a number of partners including Canadian Heritage and the Canada Council for the Arts. “Ryerson had no idea that one of the first hip-hop shows in Canada came out of Jorgenson Hall in the basement. That was Ron Nelson’s show,” says Campbell, an adjunct professor at the RTA School of Media. “That should be part of Canada’s pride across the world.” Advertisement Campbell is also the lead developer of a new think tank in the faculty of communication and design at Ryerson, where he will develop strategies and partnerships to promote Canadian culture. Facebook Login/Register With:last_img read more

Mens basketball Marc Lovings Senior Day and fight for firstday bye in

Ohio State senior forward Marc Loving defends Nebraska guard Glynn Watson Jr during a game on Feb. 18 at the Schottenstein Center. Credit: Alexa Mavrogianis | Photo EditorIn the era of Ohio State men’s basketball under coach Thad Matta, the last game of the regular season has almost always had significance. From Matt Sylvester’s game-winning 3 against No. 1 Illinois in Matta’s first season, to clinching Big Ten championships, Matta has done his job in sending seniors out in the correct fashion.On Sunday, when the Buckeyes (17-13, 7-10 Big Ten) battle the Indiana Hoosiers (16-14, 6-11 Big Ten), senior forward Marc Loving will be honored as the lone senior in the 2017 class.“(Senior Days are) a little bit emotional, but you’re happy for the individual and I think in Marc’s case, I’m very excited,” Matta said. “Just from the growth that he’s made — he’s had some ups and down throughout his career, but I see it every day.”Loving came to OSU as one of the most revered players to ever come from the competitive Toledo, Ohio, area. He was ranked as the 61st best player in the class of 2013, but many feel he never reached his full potential. Loving was asked to become a leader as a junior because of the lack of seniority on the team. His shooting percentage has gone down significantly since his sophomore season, yet remains one of OSU’s best scoring options at 12.5 points per game.Loving said he’s not one to be emotional, but can look back on his career and know how far he has grown in the program.“Coming into Ohio State, I really didn’t have any expectations,” he said. “I mean, I didn’t know how much playing time I was going to get. I wasn’t promised anything. You have to earn your spot.”Normally when OSU hosts the Hoosiers at the end of the season, the hype is palpable. Not too long ago, Indiana and the Buckeyes swung at each other for the conference crown, but injuries and other factors have led OSU and Indiana to the bottom of the Big Ten in 2016-17.However, that’s not to say the game isn’t significant. If OSU defeats the Hoosiers, the Buckeyes guarantee themselves a bye on Wednesday — the first day of the Big Ten tournament — and will be the 10 seed in the tournament.IndianaCoach Tom Crean’s squad is ranked No. 49 in Ken Pomeroy’s advanced statistical ratings, where OSU checks in at No. 66. The Hoosiers average 115.6 points per 100 possessions, which ranks 31st in the country.For any team in college basketball, especially those in major conferences like the Big Ten, it’s difficult to play without leading scorers. OSU has played without junior forward Keita Bates-Diop since the first conference game on Jan. 1. But when a team loses two of those players, it’s near impossible to overcome.Crean has desperately tried to keep his team afloat with senior forward Collin Hartman and sophomore guard OG Anunoby — a former candidate for Big Ten Player of the Year — sidelined for the season with injuries, but Indiana has been sliding as of late.Losers of six of their last seven games, the Hoosiers are also fighting to avoid the first day of the Big Ten tournament next week in Washington D.C. To do that, their top three scorers will need to do damage to the Buckeye defense in the halfcourt. Junior guards James Blackmon Jr. and Robert Johnson average 16.8 and 12.8 points per game, with sophomore center Thomas Bryant adding another 12.8.Johnson and Bryant were two players who were in foul trouble in the Hoosiers’ last game against Purdue, which ultimately crowned the Boilermakers as regular-season champs. OSU isn’t a great rebounding team, so staying out of foul trouble and owning the boards could be a vital piece to the puzzle for an Indiana victory.Another key for Indiana is if Johnson can end his shooting slump. Since Indiana started its skid on Feb. 5 at Wisconsin, Johnson is shooting 20 for 67 (29.9 percent) from the field. But like the Hoosiers have as a team — sporting victories over No. 1 Kansas and No. 5 North Carolina — Johnson has shown ability to catch fire quickly.“They’re a tough matchup in terms of what they do and what they’re capable of doing,” Matta said. “Our defense has got to be at an all-time high tomorrow or we’re in trouble.”Indiana’s defense is one of the worst in the Big Ten, allowing over 77 points per game in conference play. OSU sophomore guard JaQuan Lyle is leading the conference in 3-point shooting at 51 percent in league games. Lyle is also coming off two of his best games of the season, scoring 17 points each in wins over Wisconsin and Penn State.Matta said that he wouldn’t be surprised to see Lyle and fellow sophomore point guard C.J. Jackson play 30 minutes apiece.Prediction: Ohio State – 74, Indiana – 69 read more

Schmeichel hopes Leicester defender commits future to the club

Schmeichel hopes Leicester defender commits future to the club

first_imgLeicester City’s Kasper Schmeichel is hoping club teammate Harry Maguire ends speculation surrounding his future and commit to the club.Jamie Vardy, Wilfred Ndidi and now Schmeichel have committed their futures to Leicester City, and the Denmark international hopes defender HarryMaguire will be the next to sign up for the project. The defender was a subject of summer interest from Manchester United after an impressive outing at this summer’s World Cup with England and the Foxes are keen to tie him down at the club by offering him a new contract.Schmeichel, who signed a new five-year deal on Friday, said everyone would love to see Maguire agree a new contract, but no one would put any pressure on him.Harry Maguire, Manchester UnitedLiverpool legend Nicol slams Harry Maguire’s Man United form Andrew Smyth – September 14, 2019 Steve Nicol believes Harry Maguire has made some “horrendous mistakes” recently, and has failed to find his best form since joining Manchester United.“I hope Harry signs but I don’t want to put pressure on anyone,” said Schmeichel, according to LeicesterMercury.“It is up to him, his family and his situation. I am not going to start saying anything about his situation because I don’t know enough about it.”“If he feels it is something he wants to do then we would be delighted, but it is up to him.”City certainly showed signs of their youthful promise during the 2-1 defeat to Liverpool at the King Power Stadium.last_img read more

Reiss Nelson drops a hint over Arsenal future

Reiss Nelson drops a hint over Arsenal future

first_imgArsenal loan star Reiss Nelson has stated that he aims to become a club legend as he dropped a hint of a possible return in JanuaryThe 18-year-old forward has already bagged six goals in seven appearances on loan at Hoffenheim this season.Following Danny Welbeck’s horrific injury last week, Nelson has been tipped to make an early return to the Emirates Stadium.Now the teenage star himself hinted that it could happen while discussing his plans to become an Arsenal legend.“Arsenal are my boyhood club,” Nelson told BBC.Jadon SanchoMerson believes Arsenal should sign Sancho Manuel R. Medina – September 14, 2019 Borussia Dortmund winger Jadon Sancho might be the perfect player to play for the Gunners, according to former England international Paul Merson.“I’ve been with them since I was eight, so that’s 10 years.“I just want to go back there stronger because at the time I was at Arsenal I was 16, 17 and I didn’t feel confident.“I didn’t think I was a man, but now I’m feeling stronger and I think a couple more months or even a year in Hoffenheim will make me strong and give me the belief and confidence to go back to Arsenal and do very good there.“I want to be an Arsenal legend. And, for England, it’s the best. You can’t beat playing for your country I don’t think.”Nelson made 15 appearances for Arsenal last season and signed a new long-term contract with the Gunners in the summer.last_img read more

Full Show Sen Ted Cruz Candidate Interview and Activist DeRay Mckesson Sept

Full Show Sen Ted Cruz Candidate Interview and Activist DeRay Mckesson Sept

first_img 00:00 /50:44 To embed this piece of audio in your site, please use this code: Listencenter_img X On Thursday’s Houston Matters: HISD could disband its special education committee this week. It’s one of many decisions the school board will consider as it reviews the group’s latest recommendations on how to improve special education in the district. News 88.7’s Laura Isensee explains what’s at stake ahead of tonight’s school board meeting.Also this hour: We continue our series of candidate interviews with Republican Sen. Ted Cruz, who’s running for re-election.Then DeRay Mckesson talks about what led him to join protestors in Ferguson, Mo. and eventually quit his job in education to take up activism full time. He’s the host of the podcast Pod Save the People and has a new book called The Other Side of Freedom: The Case for Hope. He has an event in Houston Sept. 14.And a new book called Collision looks back at Houston’s contemporary art scene in the 70s and 80s.We offer a daily podcast here, on iTunes, Stitcher and other podcasting apps. This article is part of the Houston Matters podcast Sharelast_img read more

Howard University Explores Business and Economic Development in South Africa

Howard University Explores Business and Economic Development in South Africa

first_imgApproximately 100 students participated in the April 15 panel discussion at the Howard University School of Business. The topic of the day, “Business and Economic Development in South Africa: The Mandela Legacy and the 20th Anniversary of Democracy in South African.The event was organized by the Howard University School of Business, in conjunction with the Center for Global Business Studies and the Howard University Republic of South Africa Project. Former president of Bennett College Julianne Malveaux moderated the discussion. The panel included former U.S. ambassador to South Africa Donald Gips; musician and activist Hugh Masekela; partner at Nixon Peabody Kendal Tyre; stakeholder relations manager for the Department of Arts and Culture, Ministry in South Africa Zwelibanzi Ndlovu; and third-year doctoral student at the Department of African Studies Phiwo Mnyandu.After the introductions, each panelist reflected on the changes and challenges of South Africa’s development, reconstruction, and economic opportunities in the 20 years of the country’s democracy.Masekela touched on the economic isolation of the period before the country transitioned from apartheid to democracy. Because of apartheid, countries and organizations around the world halted trade with South Africa. In the United States, organizations like the Congressional Black Caucus played a key role in corporate divestment of South African holding, in an effort to force an end to apartheid and segregation.After apartheid ended in 1994, most sanctions imposed on South Africa by the international community were lifted. “After 1994, I think we freed the business establishment of South Africa that was basically White owned,” said Masekela.Masekela said that to date, people who run the major industries in the country are hanging on to their wealth, refusing to share it with the rural townships. “Nothing has really trickled down to the ordinary, especially African men and women in South Africa,” he said. “There is a very small willingness by the business establishment to include the previously disadvantaged communities.”Looking at the country’s global stance today, Mnyandu said that South Africans are in a limbo between sadness and hopefulness that the country is still making an effort to improve its economic development.Christian Boyd, a freshman international business major from Michigan, asked the panelists if Nigeria’s economic growth, surpassing South Africa as the largest economy, was a good or bad thing for the African continent. Ndlovu said it was good because it was a positive step for the continent as a whole to create a friendly competition between countries in Africa. “If there is another giant, it gives us a challenge to do more as a country,” said Ndlovu.Boyd was impressed with his response. “I got the gist of it because basically he was saying that this was finally something South Africa needed … someone to compete with in terms of growth and their future,” Boyd saidJaelin White, 18, asked Tyre, who deals with franchise companies, manufacturing, and financial services companies on the African continent, how international companies who come into South Africa conserve the cultural aspect of the country.Tyre said franchising is just a way of doing business and 90 percent of the companies franchised are South African. Tyre added that the populous of the country gets to decide what product will succeed and what will fail.last_img read more

The future cometh Science technology and humanity at Singularity Summit 2011 Part

The future cometh Science technology and humanity at Singularity Summit 2011 Part

first_img Copyright 2011 PhysOrg.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of PhysOrg.com. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. That’s really the big frontier right now is for computers, in general, to master human emotions.Emotion is not some sideshow to human intelligence. It’s actually the most complicated intelligent thing we do, being funny, getting the joke, expressing a loving sentiment. That’s the cutting edge of human intelligence. If we were to say intelligence is only logical intelligence, computers are already smarter than us. I believe it’s going to be about over the next 20 years where we close that gap in terms of human superiority today in emotional intelligence. Today computers can understand human emotions in certain situations. Watson, the IBM computer that won Jeopardy, did have to understand some things about human emotion to master the language in that game, but they’re not yet at human levels. They’re getting there.True to the Singularity’s premise of accelerating technological innovation, this achievement may be arriving sooner expected: Recently, research conducted by Zoraida Callejas, David Griol and Ramón López-Cózar at the University of Granada and University of Madrid, has demonstrated a method for predicting a person’s mental state in spoken dialog from that individual’s emotional state and intention by means of a module bridging natural language understanding and dialogue management architecture.MIT wunderkind Alexander Wissner-Gross says that it will be sufficient for a post-Singularity AI to understand human feelings rather than having to develop emotive thought. In his much-anticipated talk, Planetary-Scale Intelligence, he suggested that a global human-level AI could emerge from the mathematical world of quantitative finance and high-frequency trading – and that it may already have. Alexander Wissner-Gross on “Planetary Scale Intelligence” at Singularity Summit 2011 In The Undivided Mind – Science and Imagination, filmmaker, aesthetic philosopher and ecstatic futurist Jason Silva – the speaker that most energized the crowd – called for passion and artistic sensibility to inform ideation and instantiation of the Singularity. Silva displayed this perspective by showing his short film The Beginning of Infinity, which visually expresses an epistemological epiphany. Silva is also the first guest to be interviewed on Critical Thought TV. VIDEO: THE BEGINNING OF INFINITY“What’s fantastic about having a Singularity Summit,” Silva notes, “is that it provides an anchor that gives legitimacy to these ideas – that they’re not just something on the fringe of academia. Our story then spills over into a variety of substrates – books, magazine articles, television, film, websites, and so on. However,” he points out, “I think they need to work on their aesthetic framing” – the essence of his talk – “which I hope provided an injection of art and design. As Rebecca Elson wrote in her book, A Responsibility to Awe, facts are only as interesting as the possibilities they open up to the imagination.” For Silva, one of those possibilities is our achieving the God-like qualities of immortality and omniscience long promised, but never delivered, by religion.Silva also differs from Kurzweil and Wissner-Gross in his view of emotion in coming human-analogous AIs. For example, he refers to Leonard Shlain’s Art & Physics, which Silva cites as pointing out that art and science are two sides of the same coin. Silva agrees that this appears to be supported by fMRI studies of human brain activity, which seem to show that their common ground lies in the emotional content of experience, as well as by very recent findings that visual encoding in the human ventral temporal (VT) cortex is common across individuals viewing the same movie content. “Truth,” concludes Silva, ”is a symphony.” Expert: AI computers by 2020 (PhysOrg.com) — In its essence, technology can be seen as our perpetually evolving attempt to extend our sensorimotor cortex into physical reality: From the earliest spears and boomerangs augmenting our arms, horses and carts our legs, and fire our environment, we’re now investigating and manipulating the fabric of that reality – including the very components of life itself. Moreover, this progression has not been linear, but instead follows an iterative curve of inflection points demarcating disruptive changes in dominant societal paradigms. Suggested by mathematician Vernor Vinge in his acclaimed science fiction novel True Names (1981) and introduced explicitly in his essay The Coming Technological Singularity (1993), the term was popularized by inventor and futurist Ray Kurzweil in The Singularity is Near (2005). The two even had a Singularity Chat in 2002. More information: Part II: www.physorg.com/news/2011-12-f … logy-humanity_1.htmlcenter_img Ray Kurzweil on “From Eliza to Watson to Passing the Turing Test” at Singularity Summit 2011 In his post-presentation press conference, Kurzweil was asked about the role of our evolutionarily-determined biological drives – and thereby motivation and emotion – as minds merge with machines and AI equals or surpasses human levels. Kurzweil noted that we have a remarkable ability to sublimate our drives, and we do so largely into innovation. Since he sees the purpose of technology as the transcendence of our biological limitations, one interpretation of his response is that he might well define human-like AI as being motivated by the goal of achieving unfettered, ever-accelerating innovation – and that achieving that goal will generate a positive AE (artificial emotional) state. Whether or not that’s the case, in an Australian Broadcasting Corporation interview earlier this year, Kurzweil has predicted that AI will achieve human-level emotional thought by roughly 2030: While the Singularity is not to be confused with the astronomical description of an infinitesimal object of infinite density, it can be seen as a technological event horizon at which present models of the future may break down in the not-too-distant future when the accelerating rate of scientific discovery and technological innovation approaches a real-time asymptote. Beyond lies a future (be it utopian or dystopian) in which a key question emerges: Evolving at dramatically slower biological time scales, must Homo sapiens become Homo syntheticus in order to retain our position as the self-acclaimed crown of creation – or will that title be usurped by sentient Artificial Intelligence? The Singularity and all of its implications were recently addressed at Singularity Summit 2011 in New York City.Vinge opens his groundbreaking 1993 essay with a fundamental definition of the Singularity: The acceleration of technological progress has been the central feature of this century. We are on the edge of change comparable to the rise of human life on Earth. The precise cause of this change is the imminent creation by technology of entities with greater-than-human intelligence. Science may achieve this breakthrough by several means (and this is another reason for having confidence that the event will occur):• Computers that are “awake” and superhumanly intelligent may be developed. (To date, there has been much controversy as to whether we can create human equivalence in a machine. But if the answer is “yes,” then there is little doubt that more intelligent beings can be constructed shortly thereafter.)• Large computer networks (and their associated users) may “wake up” as superhumanly intelligent entities.• Computer/human interfaces may become so intimate that users may reasonably be considered superhumanly intelligent.• Biological science may provide means to improve natural human intellect.For Kurzweil, the core of the Singularity remains the augmentation and surpassing of human biology through the accelerating evolution of technology (notably genetics, nanotechnology, and Artificial Intelligence) enabled by exponential increases in computational power and speed coupled plummeting costs and size. Not surprisingly, then, in his opening address, From Eliza to Watson to Passing the Turing Test, Kurzweil – ever the low-key evangelist – focused largely on what he described as the remarkable continuing evidentiary support for his original projections. He voiced a clear differentiation between basing our AI offspring using biologically-inspired principles and, alternatively, crafting biomorphic substrates: In short, he favors the former, viewing the latter as unnecessary. Explore further Citation: The future cometh: Science, technology and humanity at Singularity Summit 2011 (Part I) (2011, December 1) retrieved 18 August 2019 from https://phys.org/news/2011-12-future-cometh-science-technology-humanity.html Kurzweil writes that, due to paradigm shifts, a trend of exponential growth extends Moore’s law from integrated circuits to earlier transistors, vacuum tubes, relays, and electromechanical computers. He predicts that the exponential growth will continue, and that in a few decades the computing power of all computers will exceed that of human brains, with superhuman artificial intelligence appearing around the same time. Courtesy of Ray Kurzweil and Kurzweil Technologies, Inc.last_img read more

Astronomers discover bubblelike structure associated with the pulsar PSR J1015−5719

Astronomers discover bubblelike structure associated with the pulsar PSR J1015−5719

first_img(Phys.org)—Astronomers have recently identified a peculiar bubble-like structure associated with an energetic pulsar known as PSR J1015−5719. The newly found feature, designated G283.1−0.59, is most likely a polar wind nebula. The findings were presented June 9 in a paper published on the arXiv pre-print server. More information: Discovery of a Synchrotron Bubble Associated with PSR J1015-5719, arXiv:1706.02978 [astro-ph.HE] arxiv.org/abs/1706.02978AbstractWe report the discovery of a synchrotron nebula, G283.1-0.59, associated with PSR J1015-5719. Radio observations using the Molonglo Observatory Synthesis Telescope and the Australia Telescope Compact Array at 36, 16, 6, and 3 cm reveal a complex morphology. The pulsar is embedded in the “head” of the nebula with fan-shaped diffuse emission. This is connected to a circular bubble of 20″ radius and a collimated tail extending over 1′. Polarization measurements show a highly ordered magnetic field in the nebula. It wraps around the edge of the head and shows an azimuthal configuration near the pulsar, then switches direction quasi-periodically near the bubble and in the tail. Together with the flat radio spectrum observed, we suggest that this system is most plausibly a pulsar wind nebula (PWN), with the head as a bow shock that has a low Mach number and the bubble as a shell expanding in a dense environment. The bubble could act as a magnetic bottle trapping the relativistic particles. A comparison with other bow-shock PWNe with higher Mach numbers shows similar structure and B-field geometry, implying that pulsar velocity may not be the most critical factor in determining the properties of these systems. We also derive analytic expressions for the projected standoff distance and shape of an inclined bow shock. It is found that the projected distance is always larger than the true distance in three dimensions. On the other hand, the projected shape is not sensitive to the inclination after rescaling with the projected standoff distance. © 2017 Phys.org Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Pulsar wind nebulae Citation: Astronomers discover bubble-like structure associated with the pulsar PSR J1015−5719 (2017, June 19) retrieved 18 August 2019 from https://phys.org/news/2017-06-astronomers-bubble-like-pulsar-psr-j10155719.html ATCA radio intensity maps zoomed in at J1015 and the nebula G283.1−0.59 at 16, 6, and 3 cm. The 16 cm image is obtained from the off-pulse phase bins with the pulsar binning data. The crosses mark the pulsar positionand the beam sizes are shown in the lower left. Credit: Ng et al., 2017. Located some 16,600 light years away from the Earth, PSR J1015−5719 is an energetic pulsar with a spin period of 0.14 seconds and an estimated age of about 39,000 years. The pulsar was detected in 2003 by the Parkes Multibeam Pulsar Survey. Although PSR J1015−5719 is located near the gamma-ray source 3EG J1014−5705, so far no pulsed or persistent gamma-ray emission has been found at the pulsar position. Therefore, the possibility of association with this source was excluded by researchers. Moreover, follow-up infrared, optical, and X-ray observations also found no counterparts to this pulsar.Now, a team of astronomers led by C.-Y. Ng of the University of Hong Kong presents the results of new radio observations of PSR J1015−5719, which reveal an interesting structure associated with this pulsar. The observational campaign was conducted using the Molonglo Observatory Synthesis Telescope (MOST) and the Australia Telescope Compact Array (ATCA), both located in Australia. The new data allowed the researchers to reveal a nebula consisting of a diffuse head, a circular bubble, and a collimated tail.”We report the discovery of a synchrotron nebula, G283.1−0.59, associated with PSR J1015−5719. Radio observations using the Molonglo Observatory Synthesis Telescope and the Australia Telescope Compact Array at 36, 16, 6, and 3 cm reveal a complex morphology. The pulsar is embedded in the ‘head’ of the nebula with fan-shaped diffuse emission. This is connected to a circular bubble of 20″ radius and a collimated tail extending over 1′,” the scientists wrote in the paper.According to the authors of the study, G283.1−0.59 is most likely a bow-shock pulsar wind nebula (PWN). PWNe are characterized by broadband synchrotron radiation from radio to X-ray bands when they are formed as a result of interaction of pulsar wind with the ambient medium. The morphology of bow-shock PWNe includes a long collimated tail with a small bow-shock standoff distance.The team revealed that morphology of G283.1−0.59’s head resembles the shape of a classical bow shock. The results also suggest a projected stand-off distance of about 20″. Therefore, the researchers argue that the morphology of the newly discovered nebula is similar to that of other PWNe.The hypothesis that G283.1−0.59 is associated with and thus powered by PSR J1015−5719 is based on the fact that the nebula is very close in projection to the pulsar.”We suggest that this is a newly identified bow-shock PWN associated with J1015. (…) Given its peculiar properties, a chance coincidence seems very unlikely,” the paper reads.The astronomers concluded that G283.1−0.59 is an interesting rare example of a slow moving bow-shock PWN, in which the pulsar spin axis misaligns with the proper motion direction.last_img read more

Hip Headset

first_img 1 min read Growing a business sometimes requires thinking outside the box. Opinions expressed by Entrepreneur contributors are their own. November 14, 2008 Aliph Jawbone 2 Bluetooth headset CNET’s rating: 8.7 Excellent The good: The Aliph Jawbone 2 (from $105) is a fashionable Bluetooth headset with a comfortable fit and an array of noise-canceling and voice-enhancement technologies that result in amazing sound quality. The bad: The Aliph Jawbone 2 doesn’t have a volume rocker, and the LED light is located directly on top of the Talk button. The bottom line: Despite its quirks, the Aliph Jawbone 2 is quite possibly the ultimate Bluetooth headset in terms of design and sound quality.  Free Webinar | Sept. 9: The Entrepreneur’s Playbook for Going Global Register Now »last_img read more

Air Canada kicks off MontrealLima and YellowknifeVancouver service

Air Canada kicks off MontrealLima and YellowknifeVancouver service

first_img Travelweek Group << Previous PostNext Post >> Air Canada kicks off Montreal-Lima and Yellowknife-Vancouver service Tags: Air Canada MONTREAL — This past weekend was a busy one for Air Canada, which launched service between Montreal and Lima, and from Yellowknife to Vancouver.As Montreal’s first year-round link to the southern hemisphere, flight AC1942 arrived at Lima’s Jorge Chávez International Airport on the morning of Dec. 17, complementing the airline’s existing flights from Toronto and positioning it as an “important player” in the growing market between Montreal and Latin America, said Benjamin Smith, President, Passenger Airlines at Air Canada.“Air Canada is continuing its global expansion with the launch of Montreal-Lima, the first South American route from our Montreal hub that will offer business and leisure travellers as well as freight forwarders from Quebec and Atlantic Canada convenient access to Peru,” he added. “This concludes an exceptional year of growth out of Montreal-Trudeau with the introduction of eight new destinations.”Next year, Air Canada will launch service to Tokyo-Narita (Japan), Dublin (Ireland), Lisbon (Portugal) and Bucharest (Romania). Smith also added that over the past five years, Air Canada has increased capacity from Montreal by 83% and added 29 new destinations.More news:  Air Canada’s global sales update includes Managing Director, Canada & USA SalesMontreal-Lima direct service runs twice weekly and is operated by Air Canada Rouge with 282-seat Boeing 767-300ER aircraft featuring Premium Rouge and Economy class service.A day earlier on Dec. 16, Air Canada also inaugurated Yellowknife seasonal service from Vancouver, the only nonstop flights between the two cities. The daily service is offered onboard 76-seat Bombardier CRJ-705 jet aircraft and will operate until April. Next year’s seasonal service from Vancouver will kick off on Sept. 5, 2018.“We are pleased to now link Yellowknife to our Vancouver trans-Pacific hub, connecting seamlessly to and from our Asia and U.S. transborder networks to offer time savings and ease for both international visitors travelling to enjoy our country’s spectacular Aurora Borealis and Canada’s northern winter adventures, as well as for local residents. Our seasonal route will begin in early fall next year to meet the growing demand for travel to Canada’s Northwest Territories from Asia,” said Smith.center_img Share Posted by Monday, December 18, 2017 last_img read more

Cole resolution declares July 2019 Wildlife Conservation Month

Cole resolution declares July 2019 Wildlife Conservation Month

first_img Categories: Cole News State Rep. Triston Cole sponsored a plan to declare this July “Wildlife Conservation Month” in Michigan.“As an avid and passionate outdoorsman, I value sharing our state’s wildlife and recreational opportunities with friends and family, and I want to encourage all Michiganders in the month of July to go out and enjoy our state’s natural beauty, abundant wildlife, and plentiful waters,” Cole said.According to a recent study, hunting and angling activity contributes $11.2 billion to Michigan’s economy each year and creates 171,000 jobs. In North Central Michigan – which includes the 105th House District represented by Cole– hunting and fishing activities bring $960 million of economic activity.“This year is the fifth anniversary of the creation of the Michigan Wildlife Council and July 1 marks the 81st anniversary of the effective date for the Pittman-Robertson Federal Aid in Wildlife Restoration Act, which provides funding for wildlife management projects across the nation,” said Cole. “In honor of these important milestones, I am proud to lead my colleagues in recognizing our state’s conservation heritage.”Cole’s proposal declaring July 2019 “Wildlife Conservation Month” is House Resolution 137. 25Jun Cole resolution declares July 2019 ‘Wildlife Conservation Month’last_img read more

Richard Halton All seven of YouViews shareholders

Richard Halton All seven of YouViews shareholders

first_imgRichard HaltonAll seven of YouView’s shareholders have agreed to back the UK smart TV platform for at least five more years, with the BBC, ITV, Channel 4, Channel 5, BT, TalkTalk and Arqiva remaining equal shareholders. YouView has also announced that it has passed well over one million connected UK homes in the 18 months since its marketing launch.The outfit said that over three million video-on-demand plays were being requested each week, with over half of YouView’s customers watching four half-hour VoD programmes each week.YouView did not reveal the financial commitments made by its shareholders. Reports earlier this week suggested that the broadcasters shareholders were seeking to reduce their funding of the platform by up to 85%, with BT and TalkTalk, which have arguably benefited far more from the platform, taking up the slack.“We are delighted that all seven shareholders have committed to the future of YouView with a five year term. We have achieved a significant milestone with well over 1 million homes regularly using the service and high levels of usage and satisfaction as key indicators of success for the future,” said Richard Halton, YouView’s CEO.“The next phase for YouView involves ambitious developments across a range of devices and we’re looking forward to achieving our long term target of 10 million connected UK homes.”last_img read more

The Dress Code for This New Restaurant Is Your Birthday Suit

first_img Add to Queue Opinions expressed by Entrepreneur contributors are their own. Niche marketing Twin brothers in Paris left the insurance business to open a restaurant catering to nude vegans. Contributor President of The Marks Group Image credit: O’naturel | Facebook Next Article Apply Now » The only list that measures privately-held company performance across multiple dimensions—not just revenue. –shares 3 min read Gene Marks 2019 Entrepreneur 360 List November 8, 2017 The Dress Code for This New Restaurant Is Your Birthday Suit If you’ve ever had the desire to eat an entire meal in public and be completely naked at the same time well…now’s your chance. Just go to Paris and make a reservation at O’naturel.Yes, that’s the actual name and at the 40-seat O’naturel, which opened its doors last week, customers are asked to leave their clothes in the cloakroom and proceed – in all their splendidness – to dine with other clothe-less patrons. The “bistronomic” menu starts around € 39 (about $45) and features vegan dishes, whitch are popular among naturists, and of course a great wine selection. This is Paris, let’s not forget.Related: Dear Entrepreneurs: Small Is Still BeautifulDon’t worry, health officials, the staff are clothed, patrons wear slippers and the seats have disposable covers.According to two reports last week here and here in Le Parisian, would-be voyeurs on the street won’t get a peep show. The establishment sports a “neutral” front, with a heavy blackout curtain and other screens covering the main windows. The entrance is designed to prevent anyone from seeing inside, even when the doors are opened. The establishment received a hearty thumbs up from members of the Association des Naturists de Paris, who were invited to be the very first diners.Related: 9 Startups Changing the Fabric of FashionThe French, being French, aren’t ruffled. In fact, residents in the restaurant’s neighborhood are mostly indifferent to its uniqueness. “When we learned what was going to be here, obviously it made us laugh. Especially since there is a nursery next door,” one resident who lives above the restaurant said. “But it does not bother me.”Even though it’s early days, things seem to be going pretty well for Mike and Stéphane Saada, the twin-brothers who own the restaurant. The Saada twins are ex-insurance industry executives and, unsurprisingly, ardent naturists. The restaurateurs are hoping to tap into the two-million strong naturist community in France. “We have already had quite a few reservations on the Internet,” they said, adding the comments coming in on their website are “very nice.”Related: 7 Steps to Defining Your Niche MarketLots of people open up restaurants and it’s no secret that many of them fail. It’s a hard and competitive business. Which is why a potential road to success is picking a demographic — whether it’s vegans, naked people or even lovers of the Golden Girls — and (of course) serving up good food. In this highly specialized world, many smart business owners I know are zeroing in on a targeted industry and becoming excellent at a particular skill to stand out and profit. So why not excellent food that caters to the community of French naturists?Oh, and the best thing about O’naturel? Well, in my opinion, it’s that no matter how high the bill is, you’ll never feel like you’ve lost your shirt.last_img read more

Marijuana Is a 794 Million Windfall for the States That Have Legalized

first_img Guest Writer Green Entrepreneur Podcast Lawmakers loath to raise taxes but eager for new revenue are increasingly open-minded about legal marijuana. August 9, 2018 Add to Queue Marijuana Is a $794 Million Windfall for the States That Have Legalized Adult Use Image credit: Hillary Kladke | Getty Images Easy Search. Quality Finds. Your partner and digital portal for the cannabis community. Each week hear inspiring stories of business owners who have taken the cannabis challenge and are now navigating the exciting but unpredictable Green Rush. Opinions expressed by Entrepreneur contributors are their own. Next Article 3 min read There are several good reasons for state lawmakers to embrace legal adult-use marijuana — criminal justice reform, ending mass incarceration, respect for individual rights — but for many the most compelling reason is this number: $793.6 million.That is the estimated 2017 total of taxes and fees raked in by five states where adult-use marijuana is legal, according to a report from the National Cannabis Industry Association. The NCIA, founded in 2010, represents about 1,500 businesses in the marijuana industry across the United States.Much of the rhetoric advocating legal marijuana revolves around arguments such as cannabis being less dangerous than alcohol or the social justice issues surrounding the implementation of drug laws. Those are strong, valid arguments but when it comes to actually changing minds, it’s wise to remember that money really does change everything.Related: Education and Employment Is High in Cannabis-Friendly StatesA windfall where the law allows it.The cannabis economy offers ambitious entrepreneurs the chance to flourish in an already competitive environment, but it’s the money governments are bringing in that is really turning heads in many public offices around the country. The NCIA-reported revenue for just five states. The numbers (rounded) from each are:Washington — $441 millionColorado — $234 millionOregon — $68.6 millionAlaska — $6.1 millionNevada — $43.7 millionThat Nevada number is particularly eye-catching because the state only started regulated sales of marijuana in July 2017.For state governments, there is simply nothing else aside from a gargantuan tax increase that can generate that much additional money this fast. Many observers think the potential for a large and reliable new source of marijuana tax revenue will push more states to legalize, just as New Hampshire’s legalization of a state lottery in 1964 prompted most other states to eventually follow suit. There are currenly just six states — Alabama, Alaska, Hawaii, Mississippi, Nevada, and Utah — without a state lottery. Related: Jimmy Kimmel’s ‘Dr. Quinn Medicinal Marijuana Woman’ Spoof Is HilariousEstimates of potential marijuana tax revenue has energized the push for legalization in other states.This talk heated up especially in Illinois last year, with even the Chicago Tribune weighing in that legalizing marijuana could help solve the state’s intractable budget problems. Voters will get a chance to approve recreational marijuana sales in November. However, it’s just an “advisory” ballot question. State lawmakers would still need to act. But a majority “yes” vote on legal adult-use cannabis would give lawmakers on the fence the political cover they need to move forward on legalization.Late last year, the Pennsylvania auditor general also advocated legalized marijuana to solve that state’s budget crisis, conservatively estimating $200 million in new revenue.Legalizing and taxing adult-use recreational marijuana is an increasingly viable option for states. The biggest barrier, as always, is lawmakers and state executives who led these states into a budget crisis in the first place. Voters who remember the promise of those who promoted state lotteries also might be skeptical about what marijuana tax dollars can accomplish.That said, for embattled state leaders, legalizing adult-use marijuana is a path more and more are willing to take — or at least seriously consider.Follow dispensaries.com on Instagram to stay up to date on the latest cannabis news. –shares dispensaries.com Legal Marijuana Listen Nowlast_img read more

SocketLabs Names New Chief Revenue Officer to Drive Next Wave of Growth

first_img crmemail delivery solutionsKeith HontzMarketing Technology NewsNewsSAPSocketLabs Previous ArticleValassis Research: Digital Dads Crave Shopping Convenience and Cross-Channel DealsNext ArticleComcast Business Earns Seven 2019 American Business Awards Including Recognition as Most Innovative Company of the Year SocketLabs Names New Chief Revenue Officer to Drive Next Wave of Growth in Email Delivery Market PRNewswireJune 10, 2019, 1:13 pmJune 10, 2019 SocketLabs, an industry-leading provider of highly scalable email delivery solutions that drive customer engagement and growth, is pleased to announce the appointment of Keith Hontz as Chief Revenue Officer.Keith Hontz, top performer over two decades with SAP, joins @socketlabs as its first chief revenue officer to drive next wave of growth in email delivery marketHontz joins SocketLabs from SAP America, Inc., where he was Global Vice President of SAP Industries. With over two decades of experience as a top performer in roles spanning sales, business development, product management, presales and consulting, Hontz brings an extensive background in customer experience solutions and engaging with enterprise and mid-market accounts. Most recently at SAP, he served as an executive advisor to tech start-ups at the SAP.iO Foundry in New York City, imparting his enterprise selling experience and entrepreneurial spirit.As a dynamic software executive with a proven track record of success, Hontz is excited to introduce SocketLabs’ unique communication technology to an expansive network of enterprises, integration partners and ISVs. He will be overseeing the revenue engine for SocketLabs, including new customer acquisition, sales functions and strategic partnerships, – and helping to define the company’s go-to-market strategy. Hontz will also bring a new focus to key industries driving value for line-of-business executives across IT, Marketing, Sales, Service, Commerce, HR, Operations and Procurement as well as support for leading CRM vendors and application developers.Marketing Technology News: Agency Veteran Joao Machado Joins as Sabio’s SVP of Product Marketing“Keith’s track record of sales success is hard to match,” said John Alessi, SocketLabs Founder and President. “We are excited to welcome a leader of his caliber to our team and look forward to expanding our business under his guidance as our first Chief Revenue Officer.”Founded in 2007, SocketLabs has been helping organizations around the globe, across multiple industries, deliver billions of critical emails to their prospects, customers, clients and members. The company’s founders are email software specialists who began with a vision of providing the most advanced and specialized email delivery technology in a ubiquitous, cloud-based solution.Today, SocketLabs powers email delivery for some of the world’s leading brands such as ADP, Advocare, Aston Martin, APSIS, Cisco, Customer Thermometer, Deluxe, Diebold, Honeywell, IBM, MaritzCX, Ohio State University, Panera Bread, Penn State University, ProntoForms, ReMax, Siemens, TeamSupport and Warner Brothers. The SocketLabs data processing addendum enables customers to maintain compliance with GDPR.In 2018, Philadelphia-based entrepreneur and philanthropist, Chase Lenfest, purchased a controlling interest in SocketLabs.Marketing Technology News: Vidyard Expands Offering to Bring Personalized Video App to Any Sales Professional, No Matter How They Work“We see great growth potential in SocketLabs, in part because the company’s technology has already generated broad adoption and a long track record of customer success with very minimal outbound sales efforts,” said Lenfest. “Keith will be an extraordinary addition to our team as we embark on our next wave of growth with world-class companies across the globe.”“I look forward to my new role at SocketLabs, leveraging my background in enterprise software and customer experience to drive our business forward. SocketLabs is an innovative tech company with a winning team that’s poised for massive growth,” said Hontz. “The business impact of email continues to grow as a vital communication channel for enabling customer engagement, yet over 20 percent of commercial email worldwide fails to reach the intended recipient’s inbox, either getting diverted to spam folders or blocked altogether. It’s a professional privilege to support SocketLabs’ vision of helping our clients break through these barriers and enabling successful email communications that matter most for their business. Our future ahead is bright and I’m looking forward to growing the business together with our customers.”Marketing Technology News: AdQuick.com Releases Campaign Genius, so Marketers can Plan and Optimize Out of Home (OOH) Advertising Campaigns in Minuteslast_img read more

TCALM Phase 2 clinical study results offer hope for essential tremor patients

first_img Source:http://www.cavionpharma.com/ The TETRAS Activities of Daily Living (TETRAS-ADL) scale, a measure of tremor impact on daily activities (p=0.049) The Clinician Global Impression of Improvement (CGI-I), a measurement of physician-reported global improvement (p=0.001) The TETRAS Total Score (TETRAS ADL + TETRAS-PS rated by the study Investigators, p=0.029) The Goal Attainment Scale (GAS), a measure of progress toward patient-selected goals (such as dressing oneself, writing a sentence, or drinking out of a cup) (p=0.034) Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 7 2018Cavion, Inc., a leading clinical stage biotechnology company committed to developing novel therapeutics for people with neurological diseases, today announced promising results of the T-CALM Phase 2 clinical trial of its first-in-class T-type calcium channel modulator CX-8998 in essential tremor. The company plans to present results from this proof-of-concept study as a late-breaking poster on Monday, October 8 at the International Congress of Parkinson’s Disease and Movement Disorders® in Hong Kong.Multiple secondary and exploratory endpoints collectively showed that treatment with CX-8998 10mg twice daily resulted in statistically significant improvement versus placebo in activities of daily living and patient-reported and clinical outcome measures, despite the study’s primary endpoint being missed. In the study, CX-8998 demonstrated a favorable safety and tolerability profile, with patients in the drug treatment arm reporting higher levels of satisfaction with tremor control medication compared to patients on placebo.”After decades without new effective drug therapy options, we believe that the neurostabilizing effects of CX-8998 provide hope for essential tremor patients,” said Spyros Papapetropoulos, MD, PhD, Cavion’s Executive Vice President of Research & Development and Chief Medical Officer. “The data are particularly compelling given that about two-thirds of patients in the study were on standard of care treatment and significant improvement was achieved with CX-8998 on several measures in a study lasting just one month.””Essential tremor is a challenge to treat, and patients often do not respond favorably to the existing medications, many of which have been available for decades,” said Karl Kieburtz, MD, MPH, Professor of Neurology at the University of Rochester Medical Center. “Cavion’s CX-8998 has a novel mechanism of action that may provide substantive improvement, and it could be an important therapeutic contribution above and beyond what we currently have for essential tremor. I look forward to its clinical progress and further investigation. Better medications are needed to treat this common and disabling movement disorder.”T-CALM was a 28-day, double-blind, placebo-controlled Phase 2 proof-of-concept clinical trial in 95 patients with moderate to severe essential tremor, conducted at 25 sites across the United States. Patients were randomized to receive either placebo or CX-8998 titrated up to 10mg dosed twice daily (BID). A majority of subjects (64 percent) added study drug to their existing standard of care anti-tremor medication.The primary study endpoint using remote video rating of the Tremor Research Group Essential Tremor Rating Assessment Scale – Performance Subscale (TETRAS-PS), a measure of tremor severity, did not meet significance at Day 28 (p=0.696). In contrast, the same TETRAS-PS scale rated by the study investigators who observed the patients in person resulted in a significant improvement in tremor severity at Day 28 for the CX-8998 treated group compared to placebo (p=0.027). Independent analysis of the video rating process uncovered unexpected complications in implementation. Cavion is working closely with the scientific community to enhance central video rating for use in interventional studies.Related StoriesOxidative stress could play key role in the spreading of aberrant proteins in Parkinson’s diseaseOlympus Europe and Cytosurge join hands to accelerate drug development, single cell researchResearchers challenge conventional understanding of cause of Parkinson’sMultiple secondary and exploratory endpoints collectively showed statistical significance, with benefits after 28 days of treatment in patients receiving CX-8998 10mg twice daily (BID) compared to placebo in the following scales:center_img In addition, the Patient Global Impression of Change (PGI-C), a measure of patient-reported improvement, trended towards significance favoring CX-8998 (p=0.089). Kinesia One, an algorithm-based digital measure developed for Parkinson’s disease, failed to detect a treatment difference in Essential Tremor patients. Additional analyses, including patient satisfaction with control by anti-tremor medication and traditional and digital spirography, support a treatment benefit with CX-8998. The drug showed a favorable safety and tolerability profile, with the majority of adverse events mild to moderate, transient and non-recurring. No major differences between CX-8998 and placebo were observed in laboratory values, vital signs or electrocardiography.In addition to the T-CALM study for essential tremor, CX-8998 is currently being studied in T-WAVE, a multi-center Phase 2 clinical trial for generalized epilepsy with absence seizures. “The body of evidence supporting our ground-breaking approach is rapidly expanding,” said Andrew Krouse, President and CEO of Cavion. “Our pipeline of T-type calcium channel therapies extends beyond tremor to other neurological diseases that share a common pathophysiology. We look forward to initiating a Phase 3 study in tremor soon.”​last_img read more

Scientists identify skeleton key for congenital kidney disease research

first_img Source:http://ewww.kumamoto-u.ac.jp/en/ Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 31 2018Scientists in Japan have found a ‘skeleton key’ for congenital kidney disease research. Using iPS cells generated from the skin cells of a patient with a nephrin mutation, Kumamoto University scientists have successfully developed kidney tissue that exhibits the early stages of congenital kidney disease. The protein nephrin is a constituent of the kidney filtration membrane and abnormalities of this protein are commonly found in other types of kidney diseases. The results of this work are expected to unlock several doors in future kidney disease research.The kidneys are organs that filter out and discharge waste products from the blood. During this process, proteins in the blood should not leak into the urine. The membrane responsible for this filtration is part of the glomerular podocyte and nephrin is its main constituent. If there is a genetic mutation affecting the nephrin, a large amount of protein in the blood can leak into the urine resulting in congenital nephrotic syndrome. The treatment of this syndrome is radical and difficult, and the absence of a technique to artificially reproduce a mutated filtration membrane has been a bottleneck in research progress.In 2014, this Kumamoto University research group succeeded in the extremely difficult task of producing artificial kidney tissue in vitro from human iPS cells–a world first. And in 2016, they found that glomerular podocytes derived from iPS cells strongly express nephrin, that the human glomeruli readily connects with mouse blood vessels, and that induced podocytes continue to mature after transplantation into mice. With this knowledge, they applied their techniques to iPS cells derived from a single patient for their most recent project.Related StoriesNew imaging probe allows earlier detection of acute kidney failureLow dose of endotoxin could have protective effect on men at risk of acute kidney injuryBordeaux University Hospital uses 3D printing to improve kidney tumor removal surgeryFirst, they established iPS cells from the skin cells of a patient with congenital nephrotic syndrome having a single nephrin mutation. When they induced kidney tissue from these iPS cells in vitro, they found that nephrin, which should exist on the surface of the glomerular podocyte, remained inside the cell, and that almost no filtration membrane precursor could develop. When podocyte maturation was performed by transplantation into mice, nephrin, which typically moves toward the blood vessel side of normal podocytes again remained inside the patient-derived cells. In other words, the initial pathology of this congenital kidney disease was reproduced by the iPS cells derived from the diseased patient.Furthermore, when the nephrin mutation in patient-derived iPS cells were repaired and then induced into kidney tissue, the abnormalities were normalized. Put simply, the researchers found that this single mutation is the cause of the disease, and showed that it could possibly be treated by repairing the mutation.”Because we can now reproduce the pathology of congenital nephrotic syndrome, it should be much easier to explore therapeutic drugs using this podocyte,” said project leader Professor Ryuichi Nishinakamura. “Even when kidney disease develops in adults, it often begins with abnormal quantities of protein in the urine. It is believed that this is often caused by trouble in the nephrin protein of the filtration membrane. If a medication is discovered that controls nephrin protein, there is a strong possibility that it will be highly effective for kidney disease. What we have achieved here is a big step towards the development of drugs that act on podocytes and reduce proteinuria.”last_img read more